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Meta-Analysis
. 2015 May 11:21:1350-7.
doi: 10.12659/MSM.893553.

Effects of bariatric surgery on incidence of obesity-related cancers: a meta-analysis

Xiang-wu Yang  1 , Peng-zhou Li  1 , Li-yong Zhu  1 , Shaihong Zhu  1
Affiliations
Meta-Analysis

Effects of bariatric surgery on incidence of obesity-related cancers: a meta-analysis

Xiang-wu Yang et al. Med Sci Monit. .

Retraction in

Abstract

Background: The aim of this meta-analysis was to investigate possible relationships between bariatric surgery and incidence of obesity-related cancers. Obesity is an established risk factor for obesity-related cancers but the effects of bariatric surgery on incidence of obesity-related cancers are uncertain.

Material/methods: We searched 4 electronic databases to identify eligible studies: PubMed, Embase, Web of Science, and Google Scholar. Five observational studies were eligible and included in this meta-analysis. Random-effects or fixed-effects odds ratio (OR) and its corresponding 95% confidence interval (CI) were pooled.

Results: Meta-analysis of these 5 observational studies revealed that bariatric surgery was associated with a significantly (p=0.0004) reduced incidence of obesity-related cancers (OR=0.43, 95%CI, 0.27-0.69) when compared with control individuals. Pooled estimated data showed that bariatric surgery is associated with a 24% lower colorectal cancer (CRC) risk. No publication bias was detected by Egger's or Begg's tests.

Conclusions: Although bariatric surgery may significantly reduce incidence of obesity-related cancers, considering the limitations of these included studies, these findings should be confirmed by further well-designed studies.

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Figures

Figure 1
Figure 1
Flow diagram of study identification.
Figure 2
Figure 2
Forest plot of new obesity-related cancers diagnosis rates in the bariatric surgery and no surgery groups.
Figure 3
Figure 3
Forest plot of new diagnosis rates for different cancer types in the bariatric surgery and no surgery groups.
Figure 4
Figure 4
Forest plot of new CRC diagnosis rates in the bariatric surgery and no surgery groups.
See this image and copyright information in PMC

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References

    1. Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008;67(3):253–56. - PubMed
    1. Ning Y, Wang L, Giovannucci EL. A quantitative analysis of body mass index and colorectal cancer: findings from 56 observational studies. Obes Rev. 2010;11(1):19–30. - PubMed
    1. Kramer FM, Jeffery RW, Forster JL, Snell MK. Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women. Int J Obes. 1989;13(2):123–36. - PubMed
    1. Curioni CC, Lourenco PM. Long-term weight loss after diet and exercise: a systematic review. Int J Obes (Lond) 2005;29(10):1168–74. - PubMed
    1. Anderson JW, Konz EC, Frederich RC, Wood CL. Long-term weight-loss maintenance: a meta-analysis of US studies. Am J Clin Nutr. 2001;74(5):579–84. - PubMed

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