Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Aug:65:13-22.
doi: 10.1016/j.ypmed.2014.03.027. Epub 2014 Apr 8.

Body mass index and biliary tract disease: a systematic review and meta-analysis of prospective studies

Myungsook Park  1 , Da Young Song  2 , Youjin Je  3 , Jung Eun Lee  4
Affiliations
Review

Body mass index and biliary tract disease: a systematic review and meta-analysis of prospective studies

Myungsook Park et al. Prev Med. 2014 Aug.

Abstract

Objective: To evaluate the association between body mass index (BMI, kg/m(2)) and incidence of biliary tract disease.

Methods: We performed a systematic review and a meta-analysis of prospective studies by searching the database of PubMed and EMBASE published up to December 31, 2013. Outcome of interest was disease of biliary tract system (gallbladder, extrahepatic bile duct and Ampullar of Vater). We used a random-effects model to combine the study-specific relative risks (RRs) and 95% confidence intervals (95% CIs) from 22 prospective studies. We examined whether BMI was associated with a higher risk of biliary tract disease in a combined analysis.

Results: The positive association was stronger for non-cancer biliary tract disease than biliary tract cancer; combined RRs (95% CIs) comparing the top with bottom categories were 1.40 (1.15-1.65) for biliary tract cancer and 2.75 (2.35-3.15) for non-cancer biliary tract disease (P for difference<0.001). For non-cancer biliary tract disease, combined RRs (95% CIs) comparing the top with bottom categories were 3.21 (2.48-3.93) for women and 2.01 (1.66-2.37) for men (P for difference=0.04).

Conclusion: Obesity is associated with higher risks of biliary tract cancer and, to a greater extent, non-cancer biliary tract disease.

Keywords: Biliary tract diseases; Biliary tract neoplasms; Body mass index; Cholecystitis; Cholelithiasis; Gallbladder; Neoplasms; Obesity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources