Excess body weight and the risk of primary liver cancer: an updated meta-analysis of prospective studies
- PMID: 22446023
- DOI: 10.1016/j.ejca.2012.02.063
Excess body weight and the risk of primary liver cancer: an updated meta-analysis of prospective studies
Abstract
Aims: To provide a quantitative assessment of the association between excess body weight (EBW) and the risk of primary liver cancer (PLC), we performed an updated meta-analysis of prospective observational studies.
Methods: We searched PUBMED and EMBASE for studies of body mass index and the risk of PLC published through 15 th September 2011. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. The meta-regression and stratified methods were used to examine heterogeneity across studies.
Results: A total of 26 prospective studies, including 25,337 PLC cases, were included in this analysis. Overall, excess body weight (EBW: body mass index (BMI) ≥ 25 kg/m2) and obesity (BMI ≥ 30 kg/m2) were associated with an increased risk of PLC, with significant heterogeneity (EBW: SRRs 1.48, 95% CIs 1.31-1.67, P(h)<0.001, I2=83.6%; Obesity: SRRs 1.83, 95% CIs 1.59-2.11, P(h)<0.001, I2=75.0%). Subgroup analyses revealed that the positive associations were independent of geographic locations, alcohol consumption, history of diabetes or infections with hepatitis B (HBV) and/or hepatitis C virus (HCV). Obese males had a higher risk of PLC than obese females did (P=0.027). A stronger risk of PLC with EBW was observed for patients with HCV (but not HBV) infection or cirrhosis compared with the general population.
Conclusions: Findings from this meta-analysis strongly support that EBW or obesity is associated with an increased risk of PLC in both males and females.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
-
Body mass index increases risk for colorectal adenomas based on meta-analysis.Gastroenterology. 2012 Apr;142(4):762-72. doi: 10.1053/j.gastro.2011.12.050. Epub 2012 Jan 11. Gastroenterology. 2012. PMID: 22245665
-
The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans.Am J Gastroenterol. 2001 Aug;96(8):2462-7. doi: 10.1111/j.1572-0241.2001.04054.x. Am J Gastroenterol. 2001. PMID: 11513191
-
Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies.Eur J Cancer. 2011 Jul;47(11):1606-15. doi: 10.1016/j.ejca.2011.01.020. Epub 2011 Feb 25. Eur J Cancer. 2011. PMID: 21354783 Review.
-
Body mass index and risk of primary liver cancer: a meta-analysis of prospective studies.Oncologist. 2012;17(11):1461-8. doi: 10.1634/theoncologist.2012-0066. Epub 2012 Sep 6. Oncologist. 2012. PMID: 22956536 Free PMC article.
-
Hepatic steatosis in hepatitis B virus infected patients: meta-analysis of risk factors and comparison with hepatitis C infected patients.J Gastroenterol Hepatol. 2011 Sep;26(9):1361-7. doi: 10.1111/j.1440-1746.2011.06801.x. J Gastroenterol Hepatol. 2011. PMID: 21649726 Review.
Cited by
-
Pathophysiological-Based Nutritional Interventions in Cirrhotic Patients with Sarcopenic Obesity: A State-of-the-Art Narrative Review.Nutrients. 2024 Jan 31;16(3):427. doi: 10.3390/nu16030427. Nutrients. 2024. PMID: 38337711 Free PMC article. Review.
-
Trends in the burden of most common obesity-related cancers in 16 Southern Africa development community countries, 1990-2019. Findings from the global burden of disease study.Obes Sci Pract. 2023 Nov 21;10(1):e715. doi: 10.1002/osp4.715. eCollection 2024 Feb. Obes Sci Pract. 2023. PMID: 38264007 Free PMC article.
-
ANMCO (Italian Association of Hospital Cardiologists) scientific statement: obesity in adults-an approach for cardiologists.Eat Weight Disord. 2024 Jan 2;29(1):1. doi: 10.1007/s40519-023-01630-8. Eat Weight Disord. 2024. PMID: 38168872 Free PMC article. Review.
-
From Non-Alcoholic Steatohepatitis (NASH) to Hepatocellular Carcinoma (HCC): Epidemiology, Incidence, Predictions, Risk Factors, and Prevention.Cancers (Basel). 2023 Nov 17;15(22):5458. doi: 10.3390/cancers15225458. Cancers (Basel). 2023. PMID: 38001718 Free PMC article. Review.
-
Meeting at the Crossroad between Obesity and Hepatic Carcinogenesis: Unique Pathophysiological Pathways Raise Expectations for Innovative Therapeutic Approaches.Int J Mol Sci. 2023 Sep 28;24(19):14704. doi: 10.3390/ijms241914704. Int J Mol Sci. 2023. PMID: 37834153 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical