Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis
- PMID: 21233290
- PMCID: PMC3071449
- DOI: 10.1158/1940-6207.CAPR-10-0229
Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis
Abstract
Increasing evidence suggested obesity, measured by body mass index (BMI), was associated with prostate cancer-specific mortality, and its impact on biochemical recurrence was also inconclusive. We systematically searched MEDLINE, EMBASE, and bibliographies of retrieved studies up to January 5, 2010. We used random-effects meta-analysis to assess the relative risks (RR) of prostate cancer-specific mortality and biochemical recurrence associated with a 5 kg/m(2) increase in BMI. Among the six population-based cohort studies in 1,263,483 initially cancer-free men, 6,817 prostate cancer deaths occurred; a 5 kg/m(2) increase in BMI was associated with 15% (RR: 1.15, 95% confidence interval (CI): 1.06-1.25, P < 0.01) higher risk of dying of prostate cancer. In the six postdiagnosis survival studies on 18,203 patients with 932 prostate cancer deaths, a 5 kg/m(2) increase in BMI was associated with 20% higher prostate cancer-specific mortality (RR: 1.20, 95% CI: 0.99-1.46, P = 0.06). In the sixteen studies which followed 26,479 prostate cancer patients after primary treatment, a 5 kg/m(2) increase in BMI was significantly associated with 21% increased risk of biochemical recurrence (RR: 1.21, 95% CI: 1.11-1.31 P < 0.01). Elevated BMI is associated with risk of prostate cancer-specific mortality in prospective cohort studies and biochemical recurrence in prostate cancer patients. Its association with prostate cancer-specific mortality in diagnosed patients needs to be further evaluated.
©2011 AACR.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/3071449/bin/nihms264532f1.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/3071449/bin/nihms264532f2a.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/3071449/bin/nihms264532f2a.gif)
Similar articles
-
Obesity has multifaceted impact on biochemical recurrence of prostate cancer: a dose-response meta-analysis of 36,927 patients.Med Oncol. 2014 Feb;31(2):829. doi: 10.1007/s12032-013-0829-8. Epub 2014 Jan 5. Med Oncol. 2014. PMID: 24390417
-
Obesity and long-term survival after radical prostatectomy.J Urol. 2014 Oct;192(4):1100-4. doi: 10.1016/j.juro.2014.04.086. Epub 2014 Apr 21. J Urol. 2014. PMID: 24769031
-
Body mass index is not a prognostic marker for prostate-specific antigen failure and survival in Dutch men treated with brachytherapy.BJU Int. 2010 Jan;105(1):42-8. doi: 10.1111/j.1464-410X.2009.08687.x. Epub 2009 Jun 10. BJU Int. 2010. PMID: 19519759
-
Body mass index and colorectal cancer prognosis: a systematic review and meta-analysis.Tech Coloproctol. 2016 Aug;20(8):517-35. doi: 10.1007/s10151-016-1498-3. Epub 2016 Jun 24. Tech Coloproctol. 2016. PMID: 27343117 Review.
-
The association between metabolic syndrome and the risk of prostate cancer, high-grade prostate cancer, advanced prostate cancer, prostate cancer-specific mortality and biochemical recurrence.J Exp Clin Cancer Res. 2013 Feb 13;32(1):9. doi: 10.1186/1756-9966-32-9. J Exp Clin Cancer Res. 2013. PMID: 23406686 Free PMC article. Review.
Cited by
-
PC-PEP, a Comprehensive Daily Six-Month Home-Based Patient Empowerment Program Leads to Weight Loss in Men with Prostate Cancer: A Secondary Analysis of a Clinical Trial.Curr Oncol. 2024 Mar 21;31(3):1667-1688. doi: 10.3390/curroncol31030127. Curr Oncol. 2024. PMID: 38534960 Free PMC article. Clinical Trial.
-
Insulin Resistance: The Increased Risk of Cancers.Curr Oncol. 2024 Feb 13;31(2):998-1027. doi: 10.3390/curroncol31020075. Curr Oncol. 2024. PMID: 38392069 Free PMC article. Review.
-
Body mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohorts.Br J Cancer. 2024 Feb;130(2):308-316. doi: 10.1038/s41416-023-02526-1. Epub 2023 Dec 12. Br J Cancer. 2024. PMID: 38087039 Free PMC article.
-
Dietary Barriers Appear to Influence the Effects of a Dyadic Web-Based Lifestyle Intervention on Caloric Intake and Adiposity: A Mediation Analysis of the DUET Trial.Nutrients. 2023 Nov 25;15(23):4918. doi: 10.3390/nu15234918. Nutrients. 2023. PMID: 38068776 Free PMC article. Clinical Trial.
-
Impact of obese patients in ovarian cancer surgery on postoperative wound complications: A meta-analysis.Int Wound J. 2024 Apr;21(4):e14439. doi: 10.1111/iwj.14439. Epub 2023 Dec 8. Int Wound J. 2024. PMID: 38064172 Free PMC article.
References
-
- Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625–38. - PubMed
-
- MacInnis RJ, English DR. Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control. 2006;17:989–1003. - PubMed
-
- Rodriguez C, Freedland SJ, Deka A, Jacobs EJ, McCullough ML, Patel AV, et al. Body mass index, weight change, and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev. 2007;16:63–9. - PubMed
-
- Wright ME, Chang SC, Schatzkin A, Albanes D, Kipnis V, Mouw T, et al. Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer. 2007;109:675–84. - PubMed
-
- Gong Z, Neuhouser ML, Goodman PJ, Albanes D, Chi C, Hsing AW, et al. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 2006;15:1977–83. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical