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. 1998 Dec 8;95(25):14956-60.
doi: 10.1073/pnas.95.25.14956.

Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome

R S Legro  1 , D Driscoll, J F Strauss 3rd, J Fox, A Dunaif
Affiliations

Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome

R S Legro et al. Proc Natl Acad Sci U S A. .

Abstract

Our preliminary family studies have suggested that some female first-degree relatives of women with polycystic ovary syndrome (PCOS) have hyperandrogenemia per se. It was our hypothesis that this may be a genetic trait and thus could represent a phenotype suitable for linkage analysis. To investigate this hypothesis, we examined 115 sisters of 80 probands with PCOS from unrelated families. PCOS was diagnosed by the combination of elevated serum androgen levels and </=6 menses per year with the exclusion of secondary causes. The sisters were compared with 70 healthy age- and weight-comparable control women with regular menses, no clinical evidence of hyperandrogenemia, and normal glucose tolerance. Twenty-two percent of the sisters fulfilled diagnostic criteria for PCOS. In addition, 24% of the sisters had hyperandrogenemia and regular menstrual cycles. Circulating testosterone (T) and nonsex hormone-binding globulin-bound testosterone (uT) levels in both of these groups of sisters were significantly increased compared with unaffected sisters and control women (P < 0.0001 for both T and uT). Probands, sisters with PCOS, and hyperandrogenemic sisters had elevated serum luteinizing hormone levels compared with control women. We conclude that there is familial aggregation of hyperandrogenemia (with or without oligomenorrhea) in PCOS kindreds. In affected sisters, only one-half have oligomenorrhea and hyperandrogenemia characteristic of PCOS, whereas the remaining one-half have hyperandrogenemia per se. This familial aggregation of hyperandrogenemia in PCOS kindreds suggests that it is a genetic trait. We propose that hyperandrogenemia be used to assign affected status in linkage studies designed to identify PCOS genes.

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Figures

Figure 1
Figure 1
Distribution of serum androgen levels in control women (control), hyperandrogenemic sisters (HA Sister), unaffected sister, sisters with PCOS (PCOS Sister) and PCOS probands (Proband). A proband with a T value of 330 ng/dL and an HA sister with a T value of 260 ng/dl were excluded from the figure to better display the distribution of T levels.
Figure 2
Figure 2
Frequency distribution of uT levels in sisters of PCOS probands (n = 78; Upper) and control women (n = 70; Lower). The distribution of the sisters appears to be bimodal (21).
Figure 3
Figure 3
Distribution of LH and FSH levels determined in a single blood sample in control women, hyperandrogenemic sisters (HA Sister), unaffected sisters, PCOS sisters (PCOS Sister) and PCOS probands (Probands). Two HA sisters with LH levels of 135 and 138 milliunits/ml, respectively, were excluded from the figure to better show the distribution of LH values.
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