Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings
- PMID: 9794011
- DOI: 10.1017/s0033291798006849
Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings
Abstract
Background: Neuropsychological and imaging studies suggest that frontal dysfunction may occur in apparently normal chronic alcoholic subjects.
Methods: To investigate this issue further, we performed neuropsychological and fluorodeoxy-glucose-PET studies in 17 chronic alcoholics without patent neurological and psychiatric complications.
Results: Metabolic abnormalities were found in the mediofrontal and in the left dorsolateral prefrontal cortex, but not in the orbitofrontal cortex. Neuropsychological testing revealed significantly reduced verbal fluency and impaired performance on the Stroop test. The mediofrontal hypometabolism correlated with the reduction in verbal fluency and the time necessary to perform the interference condition of the Stroop test. The left dorsolateral prefrontal hypometabolism correlated with the number of errors on the Stroop test.
Conclusion: These data indicate that circumscribed frontal dysfunctions may occur in chronic alcoholic subjects before clinically obvious neurological complications, and may account for some of the alcohol-related neuropsychological and behavioural impairments.
Similar articles
-
Neuropsychological deficits are correlated with frontal hypometabolism in positron emission tomography studies of older alcoholic patients.Alcohol Clin Exp Res. 1993 Apr;17(2):205-10. doi: 10.1111/j.1530-0277.1993.tb00750.x. Alcohol Clin Exp Res. 1993. PMID: 8488956
-
Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomography.Ann Neurol. 1990 Dec;28(6):775-85. doi: 10.1002/ana.410280608. Ann Neurol. 1990. PMID: 2285264
-
Decreased cerebral response to inhibitory neurotransmission in alcoholics.Am J Psychiatry. 1993 Mar;150(3):417-22. doi: 10.1176/ajp.150.3.417. Am J Psychiatry. 1993. PMID: 8382010
-
[Prefrontal lobes and the attentional control: a neuropsychological study using modified Stroop test].Rinsho Shinkeigaku. 2001 Dec;41(12):1134-6. Rinsho Shinkeigaku. 2001. PMID: 12235818 Review. Japanese.
-
[Hypofrontality and negative symptoms in schizophrenia: synthesis of anatomic and neuropsychological knowledge and ecological perspectives].Encephale. 2001 Sep-Oct;27(5):405-15. Encephale. 2001. PMID: 11760690 Review. French.
Cited by
-
Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence.Acta Neuropathol Commun. 2023 Jun 21;11(1):101. doi: 10.1186/s40478-023-01597-8. Acta Neuropathol Commun. 2023. PMID: 37344865 Free PMC article.
-
Functional and Structural Alteration of Default Mode, Executive Control, and Salience Networks in Alcohol Use Disorder.Front Psychiatry. 2021 Oct 20;12:742228. doi: 10.3389/fpsyt.2021.742228. eCollection 2021. Front Psychiatry. 2021. PMID: 34744834 Free PMC article.
-
Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis.Psychiatry Res Neuroimaging. 2021 Nov 30;317:111380. doi: 10.1016/j.pscychresns.2021.111380. Epub 2021 Aug 29. Psychiatry Res Neuroimaging. 2021. PMID: 34482052 Free PMC article.
-
Bidirectional causality between addiction and cognitive deficits.Int Rev Neurobiol. 2021;157:371-407. doi: 10.1016/bs.irn.2020.11.001. Epub 2020 Dec 30. Int Rev Neurobiol. 2021. PMID: 33648674 Free PMC article. Review.
-
Chronic Alcohol Exposure Induces Aberrant Mitochondrial Morphology and Inhibits Respiratory Capacity in the Medial Prefrontal Cortex of Mice.Front Neurosci. 2020 Oct 22;14:561173. doi: 10.3389/fnins.2020.561173. eCollection 2020. Front Neurosci. 2020. PMID: 33192248 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical