Evidence for striatal dopamine release during a video game
- PMID: 9607763
- DOI: 10.1038/30498
Evidence for striatal dopamine release during a video game
Abstract
Dopaminergic neurotransmission may be involved in learning, reinforcement of behaviour, attention, and sensorimotor integration. Binding of the radioligand 11C-labelled raclopride to dopamine D2 receptors is sensitive to levels of endogenous dopamine, which can be released by pharmacological challenge. Here we use 11C-labelled raclopride and positron emission tomography scans to provide evidence that endogenous dopamine is released in the human striatum during a goal-directed motor task, namely a video game. Binding of raclopride to dopamine receptors in the striatum was significantly reduced during the video game compared with baseline levels of binding, consistent with increased release and binding of dopamine to its receptors. The reduction in binding of raclopride in the striatum positively correlated with the performance level during the task and was greatest in the ventral striatum. These results show, to our knowledge for the first time, behavioural conditions under which dopamine is released in humans, and illustrate the ability of positron emission tomography to detect neurotransmitter fluxes in vivo during manipulations of behaviour.
Similar articles
-
Striatal dopaminergic dysfunction at rest and during task performance in writer's cramp.Brain. 2013 Dec;136(Pt 12):3645-58. doi: 10.1093/brain/awt282. Epub 2013 Oct 21. Brain. 2013. PMID: 24148273 Free PMC article.
-
Positron emission tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson's disease.Mov Disord. 1990;5(1):55-9. doi: 10.1002/mds.870050114. Mov Disord. 1990. PMID: 2136932
-
Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11816-20. doi: 10.1073/pnas.90.24.11816. Proc Natl Acad Sci U S A. 1993. PMID: 8265632 Free PMC article.
-
Computer and video game addiction-a comparison between game users and non-game users.Am J Drug Alcohol Abuse. 2010 Sep;36(5):268-76. doi: 10.3109/00952990.2010.491879. Am J Drug Alcohol Abuse. 2010. PMID: 20545602 Review.
-
The dopaminergic basis of human behaviors: A review of molecular imaging studies.Neurosci Biobehav Rev. 2009 Jul;33(7):1109-32. doi: 10.1016/j.neubiorev.2009.05.005. Epub 2009 May 27. Neurosci Biobehav Rev. 2009. PMID: 19481108 Free PMC article. Review.
Cited by
-
Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia.Transl Psychiatry. 2024 May 28;14(1):218. doi: 10.1038/s41398-024-02945-5. Transl Psychiatry. 2024. PMID: 38806461 Free PMC article. Clinical Trial.
-
Is Virtual Reality Orientation Therapy Useful to Optimize Cognitive and Behavioral Functioning Following Severe Acquired Brain Injury? An Exploratory Study.Brain Sci. 2024 Apr 23;14(5):410. doi: 10.3390/brainsci14050410. Brain Sci. 2024. PMID: 38790389 Free PMC article.
-
Bimodal Transformer with Regional EEG Data for Accurate Gameplay Regularity Classification.Brain Sci. 2024 Mar 15;14(3):282. doi: 10.3390/brainsci14030282. Brain Sci. 2024. PMID: 38539670 Free PMC article.
-
Advice for smokers in smoking cessation clinic: a review.Afr Health Sci. 2023 Jun;23(2):374-379. doi: 10.4314/ahs.v23i2.42. Afr Health Sci. 2023. PMID: 38223627 Free PMC article. Review.
-
The longitudinal associations between internet addiction and ADHD symptoms among adolescents.J Behav Addict. 2024 Jan 9;13(1):191-204. doi: 10.1556/2006.2023.00080. Print 2024 Mar 26. J Behav Addict. 2024. PMID: 38206342 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
