The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes
- PMID: 9538962
- DOI: 10.2337/diacare.21.1.2
The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes
Abstract
Objective: To determine whether an intermittent very-low-calorie diet (VLCD) improves weight loss and glycemic control more than moderate caloric restriction alone.
Research design and methods: Individuals with type 2 diabetes (n = 54) who were > or = 20% over ideal body weight participated in a 20-week behavioral weight control program. Subjects were randomized to either a standard behavioral therapy (SBT) group or to one of two VLCD groups. SBT subjects received a 1,500-1,800 kcal/day diet throughout. Both VLCD groups followed a VLCD for 5 consecutive days during week 2, followed by either intermittent VLCD therapy for 1 day/week for 15 weeks (1-day) or for 5 consecutive days every 5 weeks (5-day), with a 1,500-1,800 kcal/day diet at other times.
Results: Both VLCD groups lost more weight than the SBT group over the 20 weeks (P = 0.04). Although the groups did not differ in fasting plasma glucose (FPG) changes at 20 weeks, more subjects in the 5-day group attained a normal HbA1c when compared with the SBT group (P = 0.04). This benefit was independent of the effects of weight loss. The best predictor of overall change in FPG and HbA1c was the FPG response during the first 3 weeks of the program.
Conclusions: Periodic VLCDs improved weight loss in diabetic subjects. A regimen with intermittent 5-day VLCD therapy seemed particularly promising, because more subjects in this group attained a normal HbA1c. Moreover, the glucose response to a 3-week period of diet therapy predicted glycemic response at 20 weeks, and it was a better predictor of the 20-week response than initial or overall weight loss.
Similar articles
-
Effects of a behavioral weight loss program stressing calorie restriction versus calorie plus fat restriction in obese individuals with NIDDM or a family history of diabetes.Diabetes Care. 1995 Sep;18(9):1241-8. doi: 10.2337/diacare.18.9.1241. Diabetes Care. 1995. PMID: 8612437 Clinical Trial.
-
Year-long weight loss treatment for obese patients with type II diabetes: does including an intermittent very-low-calorie diet improve outcome?Am J Med. 1994 Oct;97(4):354-62. doi: 10.1016/0002-9343(94)90302-6. Am J Med. 1994. PMID: 7942937 Clinical Trial.
-
The effect of high- and low-glycemic index energy restricted diets on plasma lipid and glucose profiles in type 2 diabetic subjects with varying glycemic control.J Am Coll Nutr. 2002 Apr;21(2):120-7. doi: 10.1080/07315724.2002.10719204. J Am Coll Nutr. 2002. PMID: 11999539 Clinical Trial.
-
[Very-low-calorie-diets: is there a place for them in the management of the obese diabetic?].Diabetes Metab. 2000 Jun;26 Suppl 3:46-51. Diabetes Metab. 2000. PMID: 10945153 Review. French.
-
A Systematic Review of Evidence on the Use of Very Low Calorie Diets in People with Diabetes.Curr Diabetes Rev. 2017;13(1):35-46. doi: 10.2174/1573399812666151005123431. Curr Diabetes Rev. 2017. PMID: 26435354 Review.
Cited by
-
Health Benefits of Intermittent Fasting.Microb Physiol. 2024;34(1):142-152. doi: 10.1159/000540068. Epub 2024 Jul 2. Microb Physiol. 2024. PMID: 38955141 Review.
-
Effect of Intermittent vs. Continuous Energy Restriction on Visceral Fat: Protocol for The Healthy Diet and Lifestyle Study 2 (HDLS2).Nutrients. 2024 May 14;16(10):1478. doi: 10.3390/nu16101478. Nutrients. 2024. PMID: 38794715 Free PMC article.
-
The effects of different intermittent fasting regimens in people with type 2 diabetes: a network meta-analysis.Front Nutr. 2024 Jan 25;11:1325894. doi: 10.3389/fnut.2024.1325894. eCollection 2024. Front Nutr. 2024. PMID: 38332802 Free PMC article.
-
Effect of Intermittent Fasting on Glycaemic Control in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials.touchREV Endocrinol. 2023 May;19(1):25-32. doi: 10.17925/EE.2023.19.1.25. Epub 2023 Jan 17. touchREV Endocrinol. 2023. PMID: 37313231 Free PMC article. Review.
-
Intermittent energy restriction vs. continuous energy restriction on cardiometabolic risk factors in patients with metabolic syndrome: a meta-analysis and systematic review.Front Nutr. 2023 May 9;10:1090792. doi: 10.3389/fnut.2023.1090792. eCollection 2023. Front Nutr. 2023. PMID: 37229479 Free PMC article. Review.