In vivo imaging of neurotransmitter systems using radiolabeled receptor ligands
- PMID: 9348545
- DOI: 10.1016/S0893-133X(97)00069-9
In vivo imaging of neurotransmitter systems using radiolabeled receptor ligands
Abstract
In vivo functional brain imaging, including global blood flow, regional cerebral blood flow (rCBF), measured with positron emission tomography (PET) and single photon emission computed tomography (SPECT), and regional cerebral metabolic rate (rCMR) measured with deoxyglucose PET, have been widely used in studies of psychiatric disorders. These studies have found modest differences and required large numbers of patients. Activation studies using rCBF or rCMR as indices of neuronal activity are more sensitive because patients act as their own control; however, findings localize regions of change but provide no data about specific neurotransmitter systems. After a general discussion of the role of neurotransmitter systems in neuropsychiatric disorders, an overview of the methodology of development and selection of radioligands for PET and SPECT is presented. Studies involving PET and SPECT ligand methods are reviewed and their findings summarized, including recent work demonstrating successive mutual modulation of neurotransmitter systems. Kinetic and equilibrium analysis modeling are reviewed. The emerging methodology of measuring neurotransmitter release on activation, both pharmacologically and by task performance, using ligand methods is reviewed and proposed as a promising new approach for studying psychiatric disorders.
Similar articles
-
Neuropharmacological studies with SPECT in neuropsychiatric disorders.Nucl Med Biol. 2000 Oct;27(7):677-82. doi: 10.1016/s0969-8051(00)00135-9. Nucl Med Biol. 2000. PMID: 11091111 Review.
-
[Functional imaging in mental disorders].Orv Hetil. 2004 Feb 8;145(6):277-89. Orv Hetil. 2004. PMID: 15038321 Review. Hungarian.
-
Radiopharmaceuticals in neurological and psychiatric disorders.Curr Clin Pharmacol. 2008 May;3(2):99-107. doi: 10.2174/157488408784293679. Curr Clin Pharmacol. 2008. PMID: 18690884 Review.
-
[New receptor ligands for single-photon emission tomography of the brain].Schweiz Med Wochenschr. 1992 Oct 31;122(44):1678-88. Schweiz Med Wochenschr. 1992. PMID: 1332190 Review. German.
-
[Neuropharmacology and receptor studies in the elderly].Rev Neurol. 2002 Oct 16-31;35(8):767-77. Rev Neurol. 2002. PMID: 12402232 Review. Spanish.
Cited by
-
Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.Curr Med Chem. 2016;23(18):1818-69. doi: 10.2174/0929867323666160418114826. Curr Med Chem. 2016. PMID: 27087244 Free PMC article. Review.
-
PET studies in nonhuman primate models of cocaine abuse: translational research related to vulnerability and neuroadaptations.Neuropharmacology. 2014 Sep;84:138-51. doi: 10.1016/j.neuropharm.2013.02.004. Epub 2013 Feb 28. Neuropharmacology. 2014. PMID: 23458573 Free PMC article. Review.
-
[18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging.Eur J Nucl Med Mol Imaging. 2010 Mar;37(3):594-605. doi: 10.1007/s00259-009-1274-y. Epub 2009 Sep 30. Eur J Nucl Med Mol Imaging. 2010. PMID: 19789870
-
Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates.Eur J Nucl Med Mol Imaging. 2007 Jul;34(7):1050-60. doi: 10.1007/s00259-006-0324-y. Epub 2007 Jan 13. Eur J Nucl Med Mol Imaging. 2007. PMID: 17221184
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
