Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids
- PMID: 9026479
- PMCID: PMC1383388
- DOI: 10.1136/gut.39.5.661
Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids
Abstract
Background: The physiological relevance of duodenal bile acids in the control of cholecystokinin release and pancreatic enzyme secretion is still unknown.
Aims: To provide a near physiological situation by perfusing a bile acid mixture mimicking the individual endogenous bile acid composition of the person under investigation. For maximal reduction of endogenous bile output the CCK-A receptor antagonist loxiglumide was infused intravenously.
Subjects and methods: Seven healthy volunteers were studied on four different days by a duodenal marker perfusion technique. The individual bile acid composition in duodenal juice and test meal stimulated bile acid output was assessed on day 1. Bile acids were perfused at an amount of 30 or 100% as determined on day 1 in combination with the test meal in the presence or absence of loxiglumide. Pancreatic enzymes, bilirubin, and bile acid output were determined in duodenal juice. Plasma cholecystokinin (CCK) and plasma pancreatic polypeptide (PP) were measured radioimmunologically.
Results: Bile acid perfusion did not significantly alter stimulated pancreatic enzyme, bilirubin or bile acid output or plasma CCK. Loxiglumide did not alter basal CCK release but increased test meal stimulated CCK output fourfold (p < 0.05). The addition of bile acids to the test meal at a dose resembling 30% of bile acid output as determined on day 1 prevented this increase. Plasma PP concentration remained unchanged by bile acids and were mostly undetectable during loxiglumide infusion.
Conclusions: The CCK producing cell is under constant suppression by intraduodenal bile acids which cannot be further enhanced by a physiological bile acid mixture. However, removal of duodenal bile acids by inhibition of gall bladder contraction unmasks this suppression leading to a dramatic increase in plasma CCK levels. As little as one third of postprandially released bile acids completely reverse this effect. Bile acids are the most important luminal regulator of CCK release in humans.
Similar articles
-
Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori.J Physiol Pharmacol. 1994 Dec;45(4 Suppl 1):3-66. J Physiol Pharmacol. 1994. PMID: 7787215 Review.
-
Comparison of loxiglumide, a cholecystokinin receptor antagonist, and atropine on hormonal and meal-stimulated pancreatic secretion in man.Scand J Gastroenterol. 1990 Jul;25(7):731-8. doi: 10.3109/00365529008997600. Scand J Gastroenterol. 1990. PMID: 2396088
-
Role of bile acids in the control of pancreatic secretion and CCK release.Eur J Clin Invest. 1990 Oct;20 Suppl 1:S51-7. doi: 10.1111/j.1365-2362.1990.tb01778.x. Eur J Clin Invest. 1990. PMID: 2124998 Review.
-
Effect of a cholecystokinin antagonist on meal-stimulated insulin and pancreatic polypeptide release in humans.J Clin Endocrinol Metab. 1991 May;72(5):1123-9. doi: 10.1210/jcem-72-5-1123. J Clin Endocrinol Metab. 1991. PMID: 2022712 Clinical Trial.
-
Cholecystokinin receptor antagonist loxiglumide modulates plasma levels of gastro-entero-pancreatic hormones in man. Feedback control of cholecystokinin and gastrin secretion.Eur J Clin Invest. 1991 Oct;21(5):501-11. doi: 10.1111/j.1365-2362.1991.tb01402.x. Eur J Clin Invest. 1991. PMID: 1752290 Clinical Trial.
Cited by
-
Molecular Effects of Chronic Exposure to Palmitate in Intestinal Organoids: A New Model to Study Obesity and Diabetes.Int J Mol Sci. 2022 Jul 13;23(14):7751. doi: 10.3390/ijms23147751. Int J Mol Sci. 2022. PMID: 35887100 Free PMC article.
-
Gut Bacteria and Neuropsychiatric Disorders.Microorganisms. 2021 Dec 14;9(12):2583. doi: 10.3390/microorganisms9122583. Microorganisms. 2021. PMID: 34946184 Free PMC article. Review.
-
The Function of Gastrointestinal Hormones in Obesity-Implications for the Regulation of Energy Intake.Nutrients. 2021 May 27;13(6):1839. doi: 10.3390/nu13061839. Nutrients. 2021. PMID: 34072172 Free PMC article. Review.
-
Role of Bile Acids in the Regulation of Food Intake, and Their Dysregulation in Metabolic Disease.Nutrients. 2021 Mar 28;13(4):1104. doi: 10.3390/nu13041104. Nutrients. 2021. PMID: 33800566 Free PMC article. Review.
-
Association of Gut Hormones and Microbiota with Vascular Dysfunction in Obesity.Nutrients. 2021 Feb 13;13(2):613. doi: 10.3390/nu13020613. Nutrients. 2021. PMID: 33668627 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous