doi: 10.1126/science.274.5288.787.
Suppression of TNF-alpha-induced apoptosis by NF-kappaB
Affiliations
- PMID: 8864120
- DOI: 10.1126/science.274.5288.787
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Suppression of TNF-alpha-induced apoptosis by NF-kappaB
Science.
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Abstract
Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor NF-kappaB and programmed cell death (apoptosis). Previous studies of TNF-alpha signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-alpha-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IkappaBalpha (IkappaBalphaM). These findings suggest that a negative feedback mechanism results from TNF-alpha signaling in which NF-kappaB activation suppresses the signals for cell death.
Comment in
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Life-death balance within the cell.Science. 1996 Nov 1;274(5288):724. doi: 10.1126/science.274.5288.724. Science. 1996. PMID: 8966553 No abstract available.
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Transcription factors, oncogenes, and apoptosis.Science. 1997 Apr 11;276(5310):185. doi: 10.1126/science.276.5310.181f. Science. 1997. PMID: 9132938 No abstract available.
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