Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
- PMID: 8635662
- DOI: 10.2337/diab.45.6.832
Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
Abstract
The intestinal incretin hormone glucagon-like peptide I (GLP-I) inhibits gastric motility and secretion in normal, but not in vagotomized subjects, pointing to a centrally mediated effect. Therefore, our aim was to study the availability of rat brain GLP-I receptors to peripherally injected 125I-labeled GLP-I. The specificity of the binding was tested by co-injection of excess amounts of unlabeled GLP-I. Using light microscopical autoradiography of rat brain sections, we found specific 125I-GLP-I binding exclusively in the subfornical organ and the area postrema. This binding was abolished when an excess amount of unlabeled GLP-I was co-injected with the labeled GLP-I. We conclude that cells in the subfornical organ and the area postrema could be responsive to blood-borne GLP-I. The observed binding of peripherally administered GLP-I to the subfornical organ and the area postrema, which both have close neuroanatomical connections with hypothalamic areas involved in water and appetite homeostasis, is consistent with the potential roles of circulating GLP-I in the central regulation of appetite and autonomic functions.
Similar articles
-
Potential targets for glucagon-like peptide 2 (GLP-2) in the rat: distribution and binding of i.v. injected (125)I-GLP-2.Peptides. 2000 Oct;21(10):1511-7. doi: 10.1016/s0196-9781(00)00305-3. Peptides. 2000. PMID: 11068098
-
Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites.Eur J Neurosci. 1995 Nov 1;7(11):2294-300. doi: 10.1111/j.1460-9568.1995.tb00650.x. Eur J Neurosci. 1995. PMID: 8563978
-
Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat.Endocrinology. 1997 Oct;138(10):4445-55. doi: 10.1210/endo.138.10.5270. Endocrinology. 1997. PMID: 9322962
-
Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors.Expert Opin Emerg Drugs. 2004 May;9(1):155-66. doi: 10.1517/eoed.9.1.155.32952. Expert Opin Emerg Drugs. 2004. PMID: 15155141 Review.
-
Is glucagon-like peptide 1 an incretin hormone?Diabetologia. 1999 Mar;42(3):373-9. doi: 10.1007/s001250051165. Diabetologia. 1999. PMID: 10096792 Review.
Cited by
-
Enteroendocrine cell regulation of the gut-brain axis.Front Neurosci. 2023 Nov 7;17:1272955. doi: 10.3389/fnins.2023.1272955. eCollection 2023. Front Neurosci. 2023. PMID: 38027512 Free PMC article. Review.
-
Neurochemical Basis of Inter-Organ Crosstalk in Health and Obesity: Focus on the Hypothalamus and the Brainstem.Cells. 2023 Jul 7;12(13):1801. doi: 10.3390/cells12131801. Cells. 2023. PMID: 37443835 Free PMC article. Review.
-
Roles of bile acids signaling in neuromodulation under physiological and pathological conditions.Cell Biosci. 2023 Jun 12;13(1):106. doi: 10.1186/s13578-023-01053-z. Cell Biosci. 2023. PMID: 37308953 Free PMC article. Review.
-
Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study.Nat Metab. 2023 Jun;5(6):1059-1072. doi: 10.1038/s42255-023-00816-9. Epub 2023 Jun 12. Nat Metab. 2023. PMID: 37308722 Clinical Trial.
-
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding.JCI Insight. 2023 May 22;8(10):e164921. doi: 10.1172/jci.insight.164921. JCI Insight. 2023. PMID: 37212283 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources