Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET
- PMID: 8418276
Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET
Abstract
Positron emission tomography has been shown to provide quantitative estimates of myocardial blood flow using 13N-ammonia and 15O-water. In a validation study, myocardial blood flow was noninvasively determined in 11 open-chest anesthetized dogs using dynamic positron emission tomography. The radiopharmaceuticals 13N-ammonia and 15O-water were intravenously administered and measurements were carried out at rest and following pharmacological vasodilation to assess blood flow over a range from 53 to 580 ml/100 g/min. Quantification of blood flow based on tracer kinetic modeling of 13N-ammonia data correlated closely with myocardial blood flow determined by microspheres (y = 0.944 x +7.22, r = 0.986) and with the 15O-water injection technique y = 1.054 x -15.8 (r = 0.99). The use of 13N-ammonia with positron emission tomography enables the accurate quantification of myocardial blood flow. Using this technique, uncomplicated study protocols simplify the measurement procedures while providing excellent qualitative and quantitative information.
Similar articles
-
Quantification of myocardial blood flow using 13N-ammonia and PET: comparison of tracer models.J Nucl Med. 1999 Jun;40(6):1045-55. J Nucl Med. 1999. PMID: 10452323
-
Noninvasive quantification of hepatic arterial blood flow with nitrogen-13-ammonia and dynamic positron emission tomography.J Nucl Med. 1991 Dec;32(12):2199-206. J Nucl Med. 1991. PMID: 1744703
-
Evaluation of the novel myocardial perfusion positron-emission tomography tracer 18F-BMS-747158-02: comparison to 13N-ammonia and validation with microspheres in a pig model.Circulation. 2009 May 5;119(17):2333-42. doi: 10.1161/CIRCULATIONAHA.108.797761. Epub 2009 Apr 20. Circulation. 2009. PMID: 19380625
-
Cardiac applications of positron-emission tomography.Curr Opin Radiol. 1991 Dec;3(6):817-27. Curr Opin Radiol. 1991. PMID: 1751292 Review.
-
Quantitative evaluation of myocardial blood flow with [13N]ammonia.Cardiology. 1997 Jan-Feb;88(1):106-15. doi: 10.1159/000177316. Cardiology. 1997. PMID: 8960632 Review.
Cited by
-
Low-dose quantitative CT myocardial flow measurement using a single volume scan: phantom and animal validation.J Med Imaging (Bellingham). 2023 Sep;10(5):056002. doi: 10.1117/1.JMI.10.5.056002. Epub 2023 Oct 31. J Med Imaging (Bellingham). 2023. PMID: 37915404
-
A Reliable Production System of Large Quantities of [13N]Ammonia for Multiple Human Injections.Molecules. 2023 Jun 2;28(11):4517. doi: 10.3390/molecules28114517. Molecules. 2023. PMID: 37298995 Free PMC article.
-
Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging.Sci Rep. 2023 Jan 28;13(1):1613. doi: 10.1038/s41598-023-28643-8. Sci Rep. 2023. PMID: 36709217 Free PMC article.
-
Construction of a Phantom for Image Quality Evaluation in PET/MRI System.Ann Nucl Cardiol. 2022;8(1):103-108. doi: 10.17996/anc.22-00152. Epub 2022 Aug 31. Ann Nucl Cardiol. 2022. PMID: 36540182 Free PMC article.
-
Impact of residual subtraction on myocardial blood flow and reserve estimates from rapid dynamic PET protocols.J Nucl Cardiol. 2022 Oct;29(5):2262-2270. doi: 10.1007/s12350-021-02837-x. Epub 2021 Nov 15. J Nucl Cardiol. 2022. PMID: 34780036
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
