Evoked extracellular dopamine in vivo in the medial prefrontal cortex
- PMID: 8336146
- DOI: 10.1111/j.1471-4159.1993.tb02168.x
Evoked extracellular dopamine in vivo in the medial prefrontal cortex
Abstract
The measurement of evoked extracellular dopamine in the medial prefrontal cortex by using fast-scan cyclic voltammetry with carbon-fiber microelectrodes was established and release characteristics of mesoprefrontal dopamine neurons were examined in vivo in anesthetized rats. Despite the sparse dopaminergic innervation and the presence of more dense noradrenergic and serotonergic innervations overall in the medial prefrontal cortex, the measurement of extracellular dopamine was achieved by selective recording in dopamine-rich terminal fields and selective activation of ascending dopamine neurons. This was confirmed by electrochemical, pharmacological, and anatomical evidence. An increased release capacity for mesoprefrontal dopamine neurons was also demonstrated by the slower decay of the evoked dopamine response after inhibition of catecholamine synthesis and the maintenance of the evoked dopamine response at higher levels in the medial prefrontal cortex compared with the striatum during supraphysiological stimulation.
Similar articles
-
In vivo voltammetric measurement of evoked extracellular dopamine in the rat basolateral amygdaloid nucleus.J Physiol. 1994 Jul 15;478 ( Pt 2)(Pt 2):239-49. doi: 10.1113/jphysiol.1994.sp020246. J Physiol. 1994. PMID: 7965845 Free PMC article.
-
Effects of partial dopamine loss in the medial prefrontal cortex on local baseline and stress-evoked extracellular dopamine concentrations.Neuroscience. 1999;93(2):497-505. doi: 10.1016/s0306-4522(99)00131-1. Neuroscience. 1999. PMID: 10465433
-
Noradrenergic Modulation of Dopamine Transmission Evoked by Electrical Stimulation of the Locus Coeruleus in the Rat Brain.ACS Chem Neurosci. 2017 Sep 20;8(9):1913-1924. doi: 10.1021/acschemneuro.7b00078. Epub 2017 Jun 21. ACS Chem Neurosci. 2017. PMID: 28594540
-
Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo.Clin Chem. 2003 Oct;49(10):1763-73. doi: 10.1373/49.10.1763. Clin Chem. 2003. PMID: 14500617 Review.
-
In vivo electrochemical measurements in the CNS.Prog Neurobiol. 1990;35(4):297-311. doi: 10.1016/0301-0082(90)90014-8. Prog Neurobiol. 1990. PMID: 1980746 Review. No abstract available.
Cited by
-
Interfacing Aptamer-Modified Nanopipettes with Neuronal Media and Ex Vivo Brain Tissue.ACS Meas Sci Au. 2023 Nov 22;4(1):92-103. doi: 10.1021/acsmeasuresciau.3c00047. eCollection 2024 Feb 21. ACS Meas Sci Au. 2023. PMID: 38404490 Free PMC article.
-
To Each His Own Fear: Gender-Related Association of Anxiety, Substance Use, and Eating Disorders in a Representative Birth Cohort Sample of Young Adults with Either COMT Val158Met allele.Neuropsychobiology. 2024;83(1):41-48. doi: 10.1159/000535912. Epub 2024 Jan 16. Neuropsychobiology. 2024. PMID: 38228118 Free PMC article.
-
Dopaminergic Modulation of Prefrontal Cortex Inhibition.Biomedicines. 2023 Apr 25;11(5):1276. doi: 10.3390/biomedicines11051276. Biomedicines. 2023. PMID: 37238947 Free PMC article. Review.
-
Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales.Neuroimage. 2021 Dec 1;244:118634. doi: 10.1016/j.neuroimage.2021.118634. Epub 2021 Oct 5. Neuroimage. 2021. PMID: 34624504 Free PMC article.
-
Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans.BMC Neurosci. 2019 Apr 29;20(1):20. doi: 10.1186/s12868-019-0503-y. BMC Neurosci. 2019. PMID: 31035935 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources