Melatonin enhances the luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing hormone in the follicular, but not in the luteal, menstrual phase
- PMID: 7714075
- DOI: 10.1210/jcem.80.4.7714075
Melatonin enhances the luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing hormone in the follicular, but not in the luteal, menstrual phase
Abstract
Exogenous melatonin enhances LH pulse amplitude and mean LH levels in women during the follicular, but not the luteal, menstrual phase. In this study we investigated whether an increased pituitary response to GnRH is involved in the stimulatory effect of melatonin. Eight normal cycling women were studied on 2 consecutive days during the follicular stage (days 4-6), and eight were studied during the luteal phase (days 19-21) of the menstrual cycle. On 2 consecutive days, each women received, randomly and in a double blind fashion, placebo or 3 mg melatonin (1 mg at 0800, 1000, and 1200 h), whereas the pituitary LH and FSH responses to GnRH were tested by the iv administration of three submaximal doses of GnRH (1 microgram at 0900 h, 5 micrograms at 1100 h, and 10 micrograms at 1300 h). In the follicular phase, melatonin administration enhanced the LH and FSH responses to all three GnRH stimuli, whereas in the luteal phase, melatonin administration was ineffective. The present data indicate that an enhancing effect of melatonin on the LH and FSH responses to submaximal GnRH stimuli is evident in the follicular, but not the luteal, phase of the menstrual cycle and infer an endocrine window for the effect of melatonin on gonadotropin secretion.
Similar articles
-
[The menstrual cycle and the skin].J Dtsch Dermatol Ges. 2005 Jan;3(1):52-63; quiz 64-5. doi: 10.1046/j.1439-0353.2005.04530.x. J Dtsch Dermatol Ges. 2005. PMID: 16353751 Review. German. No abstract available.
-
Gonadotropin-releasing hormone antagonists: effects on the ovarian follicle and corpus luteum.Clin Obstet Gynecol. 1993 Sep;36(3):744-52. doi: 10.1097/00003081-199309000-00031. Clin Obstet Gynecol. 1993. PMID: 8403621 Review. No abstract available.
-
Corpus luteum insufficiency induced by a rapid gonadotropin-releasing hormone-induced gonadotropin secretion pattern in the follicular phase.J Clin Endocrinol Metab. 1987 Sep;65(3):457-64. doi: 10.1210/jcem-65-3-457. J Clin Endocrinol Metab. 1987. PMID: 3114301
-
The sequence of pituitary responses to synthetic luteinizing hormone releasing hormone (LH-RH) throughout the normal menstrual cycle.Acta Endocrinol (Copenh). 1975 Aug;79(4):625-34. doi: 10.1530/acta.0.0790625. Acta Endocrinol (Copenh). 1975. PMID: 1098349
-
Patterns of serum LH and FSH in response to 4-hour infusions of luteinizing hormone releasing hormone in normal women during menstrual cycle, on oral contraceptives, and in postmenopausal state.J Clin Endocrinol Metab. 1978 Feb;46(2):227-35. doi: 10.1210/jcem-46-2-227. J Clin Endocrinol Metab. 1978. PMID: 374423
Cited by
-
Preconception sleep duration, sleep timing, and shift work in association with fecundability and live birth among women with a history of pregnancy loss.Fertil Steril. 2023 Feb;119(2):252-263. doi: 10.1016/j.fertnstert.2022.10.026. Epub 2022 Dec 29. Fertil Steril. 2023. PMID: 36586812 Free PMC article.
-
Psychological aspects of infertility. A systematic review.J Int Med Res. 2020 Jun;48(6):300060520932403. doi: 10.1177/0300060520932403. J Int Med Res. 2020. PMID: 32600086 Free PMC article.
-
Endogenous Circadian Regulation of Female Reproductive Hormones.J Clin Endocrinol Metab. 2019 Dec 1;104(12):6049-6059. doi: 10.1210/jc.2019-00803. J Clin Endocrinol Metab. 2019. PMID: 31415086 Free PMC article.
-
Premature ovarian failure.Prz Menopauzalny. 2017 Jun;16(2):51-56. doi: 10.5114/pm.2017.68592. Epub 2017 Jun 30. Prz Menopauzalny. 2017. PMID: 28721130 Free PMC article. Review.
-
The Risk of Being Obese According to Short Sleep Duration Is Modulated after Menopause in Korean Women.Nutrients. 2017 Feb 27;9(3):206. doi: 10.3390/nu9030206. Nutrients. 2017. PMID: 28264442 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources