The use of cryopreserved human skin allografts in wound healing following Mohs surgery
- PMID: 7606373
- DOI: 10.1111/j.1524-4725.1995.tb00517.x
The use of cryopreserved human skin allografts in wound healing following Mohs surgery
Abstract
Background: Immediate reconstruction has become the preferred approach to management of full-thickness cutaneous defects following microscopically controlled excision (MCE) of tumors. In a minority of patients, however, large reconstructive procedures are contraindicated, and a long-term biological dressing that stimulates healing while minimizing wound care is desirable.
Objective: To assess the utility of cryopreserved human skin allografts (HSA) in wound care and wound healing following Mohs surgery.
Methods: Sixteen patients were treated with HSA following MCE and followed postoperatively for evidence of infection, involution, or survival of HSA, and granulation tissue production. Follow-up was 2-26 months.
Results: The use of HSA resulted in one of three general outcomes: rapid healing and rejection, subsequent full-thickness skin grafting, or persistence of HSA during prolonged healing.
Conclusions: HSA are a safe alternative to immediate reconstruction in a carefully selected population of skin cancer patients. They minimize wound care while providing continuous wound coverage during healing, and are an efficient bridge to full-thickness skin grafting.
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