Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics
- PMID: 7585146
- DOI: 10.1038/nm0795-654
Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics
Abstract
Animal studies suggest that development of substance dependence is associated with dopaminergic activity in striatum and the limbic system. Several genetic studies indicate that allele A1 is associated with both D2 receptor density and alcoholism, although these findings have remained controversial. We studied striatal dopamine (DA) re-uptake site densities in 48 subjects (19 healthy controls, 19 habitually impulsive violent alcoholics, and 10 non-violent alcoholics) with single photon emission computed tomography (SPECT) using iodine-123-labelled 2 beta-carbomethoxy-3 beta(4-iodophenyl)tropane, (beta-CIT) as a tracer. Blind quantitative analysis revealed that the striatal DA transporter density was markedly lower in non-violent alcoholics than in healthy controls (P < 0.001), while violent alcoholics had slightly higher DA transporter densities than controls (P < 0.10). The results indicate that both types of alcoholics have alterations in striatal dopaminergic system, though these occur in opposite directions.
Comment in
-
The psychobiological regulation of social cooperation.Nat Med. 1995 Jul;1(7):623-5. doi: 10.1038/nm0795-623. Nat Med. 1995. PMID: 7585135 Review. No abstract available.
-
Dopamine transporter, alcoholism and other diseases.Nat Med. 1995 Jul;1(7):624-5. doi: 10.1038/nm0795-624. Nat Med. 1995. PMID: 7585136 No abstract available.
Similar articles
-
Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour.Eur J Nucl Med. 1997 Oct;24(10):1253-60. doi: 10.1007/s002590050149. Eur J Nucl Med. 1997. PMID: 9323266
-
Abnormal structure of human striatal dopamine re-uptake sites in habitually violent alcoholic offenders: a fractal analysis.Neurosci Lett. 1998 Sep 11;253(3):195-7. doi: 10.1016/s0304-3940(98)00640-5. Neurosci Lett. 1998. PMID: 9792244
-
Dopamine transporters increase in human brain after alcohol withdrawal.Mol Psychiatry. 1999 Mar;4(2):189-91, 104-5. doi: 10.1038/sj.mp.4000514. Mol Psychiatry. 1999. PMID: 10208452
-
Applications of SPECT imaging of dopaminergic neurotransmission in neuropsychiatric disorders.Ann Nucl Med. 2000 Feb;14(1):1-9. doi: 10.1007/BF02990472. Ann Nucl Med. 2000. PMID: 10770574 Review.
-
Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism.Eur J Nucl Med. 1999 Feb;26(2):171-82. doi: 10.1007/s002590050374. Eur J Nucl Med. 1999. PMID: 9933352 Review.
Cited by
-
Effects of sedative drug use on the dopamine system: a systematic review and meta-analysis of in vivo neuroimaging studies.Neuropsychopharmacology. 2019 Mar;44(4):660-667. doi: 10.1038/s41386-018-0191-9. Epub 2018 Aug 27. Neuropsychopharmacology. 2019. PMID: 30188512 Free PMC article.
-
Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure.Handb Exp Pharmacol. 2018;248:213-238. doi: 10.1007/164_2018_106. Handb Exp Pharmacol. 2018. PMID: 29675581 Free PMC article. Review.
-
Psychopathy Moderates the Relationship between Orbitofrontal and Striatal Alterations and Violence: The Investigation of Individuals Accused of Homicide.Front Hum Neurosci. 2017 Dec 1;11:579. doi: 10.3389/fnhum.2017.00579. eCollection 2017. Front Hum Neurosci. 2017. PMID: 29249948 Free PMC article.
-
AZI23'UTR Is a New SLC6A3 Downregulator Associated with an Epistatic Protection Against Substance Use Disorders.Mol Neurobiol. 2018 Jul;55(7):5611-5622. doi: 10.1007/s12035-017-0781-2. Epub 2017 Oct 5. Mol Neurobiol. 2018. PMID: 28983843 Free PMC article.
-
Impulsive-antisocial dimension of psychopathy linked to enlargement and abnormal functional connectivity of the striatum.Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar;2(2):149-157. doi: 10.1016/j.bpsc.2016.07.004. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017. PMID: 28367514 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
