Influence of separate and combined septal and amygdala lesions on memory, acoustic startle, anxiety, and locomotor activity in rats
- PMID: 7582824
- DOI: 10.1006/nlme.1995.1055
Influence of separate and combined septal and amygdala lesions on memory, acoustic startle, anxiety, and locomotor activity in rats
Abstract
The septohippocampal system and the amygdala have been implicated in cognitive and emotional processes. A series of experiments was conducted to examine the effects of separate and combined lesions of these areas on a variety of behaviors, including: startle responses to acoustic stimuli; sensory gating, using prepulse inhibition of acoustic startle; anxiety, using the elevated plus-maze; locomotor activity in an open field; and memory, using both a spatial discrimination version of the Morris water maze and the inhibitory (passive) avoidance test. Both septal and fimbria-fornix lesions markedly impaired the acquisition of spatial information in the water maze, had anxiolytic-like effects in the elevated plus-maze, increased reactivity to footshock, and had marginal effects on prepulse inhibition and baseline startle. Septal and fimbria-fornix lesions also increased locomotor activity in the later stages of a session of open field exploration, but only septal lesions produced "freezing" during the early portion of this session and during inhibitory avoidance training. Amygdala lesions markedly impaired prepulse inhibition of acoustic startle. Amygdala lesions also attenuated the effects of septal lesions on freezing in the open field and on footshock reactivity, but did not affect the anxiolytic-like effects or hyperactivity associated with septal lesions. Amygdala lesions by themselves had no significant effect on water maze performance, but significantly potentiated the effects of septal lesions. These results suggest that there are dissociations between the effects of septal and fimbria-fornix lesions and that the interactions between the amygdala and septum in cognitive and emotional processes are task dependent.
Similar articles
-
The amygdala and emotional modulation of competition between cognitive and habit memory.Behav Brain Res. 2008 Nov 3;193(1):126-31. doi: 10.1016/j.bbr.2008.05.002. Epub 2008 May 8. Behav Brain Res. 2008. PMID: 18565602
-
N-methyl-D-aspartate receptors in the medial septal area have a role in spatial and emotional learning in the rat.Neuroscience. 2006 Nov 3;142(4):963-78. doi: 10.1016/j.neuroscience.2006.07.043. Epub 2006 Sep 6. Neuroscience. 2006. PMID: 16952425
-
Medial amygdala lesions differentially influence stress responsivity and sensorimotor gating in rats.Physiol Behav. 2010 Mar 3;99(3):395-401. doi: 10.1016/j.physbeh.2009.12.006. Epub 2009 Dec 13. Physiol Behav. 2010. PMID: 20006965
-
Amygdala in action: relaying biological and social significance to autobiographical memory.Neuropsychologia. 2011 Mar;49(4):718-33. doi: 10.1016/j.neuropsychologia.2010.10.007. Epub 2010 Oct 8. Neuropsychologia. 2011. PMID: 20933525 Review.
-
Emotional behaviour and the limbic system.Adv Psychosom Med. 1985;13:1-25. Adv Psychosom Med. 1985. PMID: 2863961 Review. No abstract available.
Cited by
-
Quinpirole, but not muscimol, infused into the nucleus accumbens disrupts prepulse inhibition of the acoustic startle in rhesus macaques.Neuropharmacology. 2023 Sep 1;235:109563. doi: 10.1016/j.neuropharm.2023.109563. Epub 2023 Apr 26. Neuropharmacology. 2023. PMID: 37116610
-
Neurodegeneration Within the Amygdala Is Differentially Induced by Opioid and HIV-1 Tat Exposure.Front Neurosci. 2022 May 4;16:804774. doi: 10.3389/fnins.2022.804774. eCollection 2022. Front Neurosci. 2022. PMID: 35600626 Free PMC article.
-
The Role of the Medial Septum-Associated Networks in Controlling Locomotion and Motivation to Move.Front Neural Circuits. 2021 Jul 22;15:699798. doi: 10.3389/fncir.2021.699798. eCollection 2021. Front Neural Circuits. 2021. PMID: 34366795 Free PMC article. Review.
-
The amygdala modulates prepulse inhibition of the auditory startle reflex through excitatory inputs to the caudal pontine reticular nucleus.BMC Biol. 2021 Jun 3;19(1):116. doi: 10.1186/s12915-021-01050-z. BMC Biol. 2021. PMID: 34082731 Free PMC article.
-
Dysregulation of behavioral and autonomic responses to emotional and social stimuli following bidirectional pharmacological manipulation of the basolateral amygdala in macaques.Neuropharmacology. 2020 Nov 15;179:108275. doi: 10.1016/j.neuropharm.2020.108275. Epub 2020 Aug 21. Neuropharmacology. 2020. PMID: 32835765 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources