Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level
- PMID: 7229749
- DOI: 10.1016/s0022-3476(81)80829-3
Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level
Abstract
The risk for hospitalization with respiratory syncytial virus infection during the first year of life was about five per 1,000 live births per year for infants born to low-income families in Houston from 1975 to 1979. The risk varied depending upon the intensity of the epidemic for a given season, the month of birth of the infant, and the level of passively acquired maternal antibody at the time of birth. Over 80% of the children hospitalized were less than 6 months of age; thus, most were born during the six months preceding the peak of RS virus activity. The neutralizing antibody titers in cord sera of 68 infants with culture-proven infections before 6 months of age were significantly lower than those of 575 randomly selected cord samples of infants born during the same period. The level of antibody at the time of birth was directly correlated with age at the time of infection. In addition, infants with more severe illnesses had lower levels of antibody in serum collected near onset of illness than did infants with milder illnesses. These observations demonstrate protection against RS infection in early infancy that is correlated with the level of maternal antibody, but it is not known if this protection is mediated directly by the passively acquired antibody or by some other mechanism.
Similar articles
-
Maternal antibody and respiratory syncytial virus infection in infancy.J Med Virol. 1981;7(4):263-71. doi: 10.1002/jmv.1890070403. J Med Virol. 1981. PMID: 7038043
-
Prevalence of respiratory syncytial virus IgG antibodies in infants living in a rural area of Mozambique.J Med Virol. 2002 Aug;67(4):616-23. doi: 10.1002/jmv.10148. J Med Virol. 2002. PMID: 12116014
-
Relation of serum antibody to glycoproteins of respiratory syncytial virus with immunity to infection in children.Viral Immunol. 1987-1988;1(3):199-205. doi: 10.1089/vim.1987.1.199. Viral Immunol. 1987. PMID: 3509676
-
[Bronchiolitis caused by respiratory syncytial virus in very young infants and transmitted maternal antibodies].Arch Fr Pediatr. 1988 Dec;45(10):791-3. Arch Fr Pediatr. 1988. PMID: 3071286 Review. French.
-
Immunopathologic mechanisms in lower respiratory tract disease of infants due to respiratory syncytial virus.Prog Med Virol. 1980;26:94-118. Prog Med Virol. 1980. PMID: 6999535 Review. No abstract available.
Cited by
-
Transfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants.Open Forum Infect Dis. 2024 Jul 22;11(7):ofae314. doi: 10.1093/ofid/ofae314. eCollection 2024 Jul. Open Forum Infect Dis. 2024. PMID: 39040482 Free PMC article.
-
Respiratory syncytial virus vaccination during pregnancy for improving infant outcomes.Cochrane Database Syst Rev. 2024 May 2;5(5):CD015134. doi: 10.1002/14651858.CD015134.pub2. Cochrane Database Syst Rev. 2024. PMID: 38695784 Review.
-
Respiratory Syncytial Virus Infections in Neonates: A Persisting Problem.Newborn (Clarksville). 2023 Jul-Sep;2(3):222-234. doi: 10.5005/jp-journals-11002-0073. Epub 2023 Sep 25. Newborn (Clarksville). 2023. PMID: 38348152 Free PMC article.
-
Development and comparison of immunologic assays to detect primary RSV infections in infants.Front Immunol. 2024 Jan 12;14:1332772. doi: 10.3389/fimmu.2023.1332772. eCollection 2023. Front Immunol. 2024. PMID: 38283339 Free PMC article.
-
Respiratory syncytial virus: A new era.Rev Esp Quimioter. 2024 Apr;37(2):134-148. doi: 10.37201/req/147.2023. Epub 2024 Jan 11. Rev Esp Quimioter. 2024. PMID: 38205560 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources