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Randomized Controlled Trial
. 2024 Aug 13;103(3):e209608.
doi: 10.1212/WNL.0000000000209608. Epub 2024 Jul 11.

Quantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome

Michel J A M van Putten  1 , Barry J Ruijter  1 , Janneke Horn  1 , Anne-Fleur van Rootselaar  1 , Selma C Tromp  1 , Vivianne van Kranen-Mastenbroek  1 , Nicolas Gaspard  1 , Jeannette Hofmeijer  1 ; TELSTAR Investigators  1
Affiliations
Randomized Controlled Trial

Quantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome

Michel J A M van Putten et al. Neurology. .

Abstract

Objectives: Rhythmic and periodic patterns (RPPs) on EEG in patients in a coma after cardiac arrest are associated with a poor neurologic outcome. We characterize RPPs using qEEG in relation to outcomes.

Methods: Post hoc analysis was conducted on 172 patients in a coma after cardiac arrest from the TELSTAR trial, all with RPPs. Quantitative EEG included corrected background continuity index (BCI*), relative discharge power (RDP), discharge frequency, and shape similarity. Neurologic outcomes at 3 months after arrest were categorized as poor (CPC = 3-5) or good (CPC = 1-2).

Results: A total of 16 patients (9.3%) had a good outcome. Patients with good outcomes showed later RPP onset (28.5 vs 20.1 hours after arrest, p < 0.05) and higher background continuity at RPP onset (BCI* = 0.83 vs BCI* = 0.59, p < 0.05). BCI* <0.45 at RPP onset, maximum BCI* <0.76, RDP >0.47, or shape similarity >0.75 were consistently associated with poor outcomes, identifying 36%, 22%, 40%, or 24% of patients with poor outcomes, respectively. In patients meeting both BCI* >0.44 at RPP onset and BCI* >0.75 within 72 hours, the probability of good outcomes doubled to 18%.

Discussion: Sufficient EEG background continuity before and during RPPs is crucial for meaningful recovery. Background continuity, discharge power, and shape similarity can help select patients with relevant chances of recovery and may guide treatment.

Trial registration information: February 4, 2014, ClinicalTrial.gov, NCT02056236.

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