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Observational Study
. 2024 Jul 5;103(27):e38826.
doi: 10.1097/MD.0000000000038826.

Association between lymphocyte-to-monocyte ratio and prostate cancer in men: A population-based study

Pingzhou Chen  1 , Zhijie Huang  2 , Xiang Wu  1
Affiliations
Observational Study

Association between lymphocyte-to-monocyte ratio and prostate cancer in men: A population-based study

Pingzhou Chen et al. Medicine (Baltimore). .

Abstract

Using the novel inflammatory biomarker lymphocyte-to-monocyte ratio (LMR), this work aimed to look into any potential connections between LMR and prostate cancer (PCa). A cross-sectional research investigation was conducted on 7706 male participants involved in the National Health and Nutrition Examination Survey from 2001 to 2010. Multivariate logistic regression modeling investigated the relationship between LMR levels and PCa risk. Furthermore, threshold analysis, subgroup analysis, interaction testing, and smoothed curve fitting were carried out. A significant negative correlation was seen between LMR and PCa risk (OR = 0.79, 95% CI: 0.65-0.97, P = .0002), even after controlling for potential confounding factors. A significant nonlinear negative correlation with a threshold effect and a breakpoint of 4.86 was found by smooth curve fitting between LMR and PCa. Subgroup analysis revealed a significant interaction (P for interaction = 0.0448) between the negative correlation between PCa and LMR about hypertension. Moreover, additional stratified smoothed curve fitting demonstrated a statistically significant inverse relationship between PCa risk and LMR. According to our findings, there is a substantial inverse relationship between PCa risk and LMR level. The inflammatory response-related index is quick, easy to use, and offers some clinical references. However, more extensive prospective investigations are required to confirm the involvement of LMR levels in PCa.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flow chart.
Figure 2.
Figure 2.
Smooth curve fitting of LMR to PCa. The solid red line represents the fitted curve between the variables. The blue solid line represents the 95% confidence interval of the fitted results. LMR = lymphocyte-to-monocyte ratio, PCa = prostate cancer.
Figure 3.
Figure 3.
Subgroup analysis.
Figure 4.
Figure 4.
Further subgroup analysis.
See this image and copyright information in PMC

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