The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom
- PMID: 3522324
- DOI: 10.1007/BF00452061
The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom
Abstract
A 25-year computerised survey of deaths in the United Kingdom among diabetic patients of 19 years of age and under was performed. Suitable pancreatic material was available in 119 out of the 498 identified patients. The duration of diabetes was known in 95 of the 119 patients. In 60 patients it had been present for less than 1 year. Insulitis was present in 47 of the 60 patients (78%) with recent onset disease, and was also found in 3 patients who had been treated for diabetes for between 1 and 6 years. In cases in which it was identified, insulitis affected 23% of islets containing insulin, but affected only 1% of islets which were insulin deficient, thus supporting the concept that insulitis represents an immunologically mediated destruction of insulin secreting B cells. Four patients appeared to have a different disease from classical Type 1 (insulin-dependent) diabetes in that there was no evidence of insulitis and all islets contained insulin. The age of onset of diabetes was eighteen months or less in these patients.
Similar articles
-
The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue.Diabetologia. 1984 Jun;26(6):456-61. doi: 10.1007/BF00262221. Diabetologia. 1984. PMID: 6381192
-
Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus.Diabetologia. 1987 May;30(5):333-43. doi: 10.1007/BF00299027. Diabetologia. 1987. PMID: 3301484 Free PMC article.
-
Insulitis in type 1 (insulin-dependent) diabetes mellitus in man--macrophages, lymphocytes, and interferon-gamma containing cells.J Pathol. 1991 Oct;165(2):97-103. doi: 10.1002/path.1711650203. J Pathol. 1991. PMID: 1744803
-
[Insulitis in type 1 diabetes].Pathologe. 2016 May;37(3):245-52. doi: 10.1007/s00292-016-0166-8. Pathologe. 2016. PMID: 27126249 Review. German.
-
Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made.Diabetologia. 2018 Dec;61(12):2499-2506. doi: 10.1007/s00125-018-4731-y. Epub 2018 Sep 25. Diabetologia. 2018. PMID: 30255378 Free PMC article. Review.
Cited by
-
Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2.Nat Rev Endocrinol. 2024 May;20(5):312. doi: 10.1038/s41574-024-00975-z. Nat Rev Endocrinol. 2024. PMID: 38514816 No abstract available.
-
Insulitis in human type 1 diabetes: lessons from an enigmatic lesion.Eur J Endocrinol. 2024 Jan 17;190(1):R1-9. doi: 10.1093/ejendo/lvae002. Online ahead of print. Eur J Endocrinol. 2024. PMID: 38231086 Free PMC article.
-
A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction.Biofabrication. 2024 Jan 11;16(2):025001. doi: 10.1088/1758-5090/ad17d0. Biofabrication. 2024. PMID: 38128127 Free PMC article.
-
Heterogeneity and endotypes in type 1 diabetes mellitus.Nat Rev Endocrinol. 2023 Sep;19(9):542-554. doi: 10.1038/s41574-023-00853-0. Epub 2023 Jun 19. Nat Rev Endocrinol. 2023. PMID: 37337007 Review.
-
Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor-Related Type 1 Diabetes in Genetically Susceptible Patients.Diabetes. 2023 Apr 1;72(4):511-519. doi: 10.2337/db22-0557. Diabetes. 2023. PMID: 36657987 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources
Medical