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. 2021 Nov 3:18:100385.
doi: 10.1016/j.bbih.2021.100385. eCollection 2021 Dec.

Preventive strategies for adolescent depression: What are we missing? A focus on biomarkers

Valentina Zonca  1   2
Affiliations

Preventive strategies for adolescent depression: What are we missing? A focus on biomarkers

Valentina Zonca. Brain Behav Immun Health. .

Abstract

Adolescent depression is an important global issue with several unmet needs that still must be addressed and, to date, there are only few effective preventive strategies to reduce the burden of this disorder worldwide. In this mini-review, the evidence and potential ways to improve an early detection will be discussed as well as prompt interventions by focusing on a better understanding of the risks underlying the developing of adolescent depression from both a sociodemographic and a biological perspective.

Keywords: Adolescent depression; Biomarkers; LMIC; Next Generation Sequencing (NGS); Preventive strategies.

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Conflict of interest statement

None.

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References

    1. Adam E.K., Doane L.D., Zinbarg R.E., Mineka S., Craske M.G., Griffith J.W. Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence. Psychoneuroendocrinology. 2010;35(6):921–931. - PMC - PubMed
    1. Babajide A., Ortin A., Wei C., Mufson L., Duarte C.S. Transition Cliffs for young adults with anxiety and depression: is integrated mental health care a solution? J. Behav. Health Serv. Res. 2020;47(2):275–292. - PMC - PubMed
    1. Bignardi G., Dalmaijer E.S., Anwyl-Irvine A.L., Smith T.A., Siugzdaite R., Uh S., Astle D.E. Longitudinal increases in childhood depression symptoms during the COVID-19 lockdown. Arch. Dis. Child. 2020;106(8):791–797. - PMC - PubMed
    1. Biomarkers Definitions Working G. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 2001;69(3):89–95. - PubMed
    1. Brathwaite R., Rocha T.B., Kieling C., Gautam K., Koirala S., Mondelli V., Kohrt B., Fisher H.L. Predicting the risk of depression among adolescents in Nepal using a model developed in Brazil: the IDEA Project. Eur. Child Adolesc. Psychiatr. 2021;30(2):213–223. - PMC - PubMed

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