WNT-β-catenin signalling - a versatile player in kidney injury and repair
- PMID: 32989282
- DOI: 10.1038/s41581-020-00343-w
WNT-β-catenin signalling - a versatile player in kidney injury and repair
Abstract
The WNT-β-catenin system is an evolutionary conserved signalling pathway that is of particular importance for morphogenesis and cell organization during embryogenesis. The system is usually suppressed in adulthood; however, it can be re-activated in organ injury and regeneration. WNT-deficient mice display severe kidney defects at birth. Transient WNT-β-catenin activation stimulates tissue regeneration after acute kidney injury, whereas sustained (uncontrolled) WNT-β-catenin signalling promotes kidney fibrosis in chronic kidney disease (CKD), podocyte injury and proteinuria, persistent tissue damage during acute kidney injury and cystic kidney diseases. Additionally, WNT-β-catenin signalling is involved in CKD-associated vascular calcification and mineral bone disease. The WNT-β-catenin pathway is tightly regulated, for example, by proteins of the Dickkopf (DKK) family. In particular, DKK3 is released by 'stressed' tubular epithelial cells; DKK3 drives kidney fibrosis and is associated with short-term risk of CKD progression and acute kidney injury. Thus, targeting the WNT-β-catenin pathway might represent a promising therapeutic strategy in kidney injury and associated complications.
Similar articles
-
The WNT/β-catenin system in chronic kidney disease-mineral bone disorder syndrome.Int Urol Nephrol. 2023 Oct;55(10):2527-2538. doi: 10.1007/s11255-023-03569-2. Epub 2023 Mar 24. Int Urol Nephrol. 2023. PMID: 36964322 Review.
-
New insights into the role and mechanism of Wnt/β-catenin signalling in kidney fibrosis.Nephrology (Carlton). 2018 Oct;23 Suppl 4:38-43. doi: 10.1111/nep.13472. Nephrology (Carlton). 2018. PMID: 30298654 Review.
-
Wnt/β-catenin signaling and renin-angiotensin system in chronic kidney disease.Curr Opin Nephrol Hypertens. 2016 Mar;25(2):100-6. doi: 10.1097/MNH.0000000000000205. Curr Opin Nephrol Hypertens. 2016. PMID: 26808707 Free PMC article. Review.
-
Wnt pathway activation in long term remnant rat model.Biomed Res Int. 2014;2014:324713. doi: 10.1155/2014/324713. Epub 2014 Jun 5. Biomed Res Int. 2014. PMID: 24995284 Free PMC article.
-
DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner.Ren Fail. 2024 Dec;46(1):2343817. doi: 10.1080/0886022X.2024.2343817. Epub 2024 Apr 29. Ren Fail. 2024. PMID: 38682264 Free PMC article.
Cited by
-
Traditional Chinese Medicine and renal regeneration: experimental evidence and future perspectives.Chin Med. 2024 Jun 3;19(1):77. doi: 10.1186/s13020-024-00935-9. Chin Med. 2024. PMID: 38831435 Free PMC article. Review.
-
Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury.Cell Mol Life Sci. 2024 May 30;81(1):244. doi: 10.1007/s00018-024-05289-x. Cell Mol Life Sci. 2024. PMID: 38814462 Free PMC article.
-
Tubular biomarkers in proteinuric kidney disease: histology correlation and kidney prognosis of tubular biomarkers.Clin Kidney J. 2024 May 9;17(5):sfae146. doi: 10.1093/ckj/sfae146. eCollection 2024 May. Clin Kidney J. 2024. PMID: 38803396 Free PMC article.
-
Puerariae lobatae Radix ameliorates chronic kidney disease by reshaping gut microbiota and downregulating Wnt/β‑catenin signaling.Mol Med Rep. 2024 Jul;30(1):117. doi: 10.3892/mmr.2024.13241. Epub 2024 May 17. Mol Med Rep. 2024. PMID: 38757304 Free PMC article.
-
N1F(Improved-Nephropathy 1 Formula) Ameliorates Renal Interstitial Fibrosis via Inhibiting Extracellular Matrix Deposition and Regulating the FGF23/P38MAPK/Wnt Pathway.Cell Biochem Biophys. 2024 May 9. doi: 10.1007/s12013-024-01244-6. Online ahead of print. Cell Biochem Biophys. 2024. PMID: 38722471
References
-
- Nusse, R. & Varmus, H. E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31, 99–109 (1982). - PubMed
-
- Nusse, R. & Clevers, H. Wnt/beta-catenin signaling, disease, and emerging therapeutic modalities. Cell 169, 985–999 (2017). - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical