Genome-wide association study of aggression and violence in schizophrenia
- PMID: 32445792
- DOI: 10.1016/j.neulet.2020.135061
Genome-wide association study of aggression and violence in schizophrenia
Abstract
Schizophrenia patients are at higher risk of engaging in violent behavior than the general population. Schizophrenia is also regarded as a highly heritable disorder. This study aimed to analyze genome-wide the effect of SNPs on violence in schizophrenia. We recruited 205 subjects between the age of 18-75 from the Centre for Addiction and Mental Health (CAMH), who had a diagnosis of schizophrenia or schizoaffective disorder. We recorded physical, verbal and lifetime violence scores indicating any violent actions to inflict pain, bodily harm, or death on another individual from the standardized scale, Modified Overt Aggression Scale (MOAS). We genotyped each participant's DNA using the Illumina Omni 2.5, and the SNPs were analyzed using the whole genome analysis tool-set, PLINK. We probed for single nucleotide polymorphisms (SNPs) correlated with violence in schizophrenia patients. We found one SNP (rs2188177) on chromosome 7 which showed a trend for association with physical violence (p = 7.80E-06). This study is the first of its kind to investigate genome-wide, the polymorphisms associated with violence in schizophrenia. The findings of this study may promote collaborative efforts to understand the genetic basis of violent behavior in psychosis.
Keywords: Aggression; GWAS; Genetics; Schizophrenia; Violence.
Copyright © 2020 Elsevier B.V. All rights reserved.
Similar articles
-
Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder.Arch Gen Psychiatry. 2006 Jun;63(6):622-9. doi: 10.1001/archpsyc.63.6.622. Arch Gen Psychiatry. 2006. PMID: 16754835 Clinical Trial.
-
Association between insight, cognitive insight, positive symptoms and violence in patients with schizophrenia.Nord J Psychiatry. 2013 Apr;67(2):116-23. doi: 10.3109/08039488.2012.687767. Epub 2012 May 23. Nord J Psychiatry. 2013. PMID: 22616874
-
Copy Number Variation Analysis of Aggressive Behaviour in Schizophrenia.Neuropsychobiology. 2024;83(2):114-120. doi: 10.1159/000533689. Epub 2023 Nov 20. Neuropsychobiology. 2024. PMID: 37984346
-
Violence in schizophrenia and bipolar disorder.Psychiatr Danub. 2013 Mar;25(1):24-33. Psychiatr Danub. 2013. PMID: 23470603 Review.
-
Research Progress on the Relationship between Genetic Polymorphism and Violent Behavior of Patients with Schizophrenia.Fa Yi Xue Za Zhi. 2020 Jun;36(3):379-378. doi: 10.12116/j.issn.1004-5619.2020.03.016. Fa Yi Xue Za Zhi. 2020. PMID: 32705854 Review. Chinese, English.
Cited by
-
Female Homicide in Italy in 2021: Different Criminological and Psychopathological Perspectives on the Phenomenon.Int J Environ Res Public Health. 2022 Jun 20;19(12):7537. doi: 10.3390/ijerph19127537. Int J Environ Res Public Health. 2022. PMID: 35742784 Free PMC article.
-
The Neutrophil-Lymphocyte Ratio Is Positively Correlated with Aggression in Schizophrenia.Biomed Res Int. 2022 Apr 23;2022:4040974. doi: 10.1155/2022/4040974. eCollection 2022. Biomed Res Int. 2022. PMID: 35502339 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical