Review

. 2020 Jul:127:110108.

doi: 10.1016/j.biopha.2020.110108. Epub 2020 Mar 29.

The emerging role of ferroptosis in inflammation

Yitian Sun¹, Peng Chen², Bingtao Zhai², Mingming Zhang², Yu Xiang², Jiaheng Fang³, Sinan Xu³, Yufei Gao³, Xin Chen³, Xinbing Sui⁴, Guoxiong Li⁵

Affiliations

¹ The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China; Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou 310018, Zhejiang, China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou 310018, Zhejiang, China.
² Holistic Integrative Pharmacy Institutes and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China; Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou 310018, Zhejiang, China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou 310018, Zhejiang, China.
³ The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China.
⁴ The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China; Holistic Integrative Pharmacy Institutes and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China; Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou 310018, Zhejiang, China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou 310018, Zhejiang, China. Electronic address: hzzju@zju.edu.cn.
⁵ The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China. Electronic address: guoxiongli849@hotmail.com.

PMID: 32234642
DOI: 10.1016/j.biopha.2020.110108

Free article

Review

The emerging role of ferroptosis in inflammation

Yitian Sun et al. Biomed Pharmacother. 2020 Jul.

Free article

. 2020 Jul:127:110108.

doi: 10.1016/j.biopha.2020.110108. Epub 2020 Mar 29.

Authors

Yitian Sun¹, Peng Chen², Bingtao Zhai², Mingming Zhang², Yu Xiang², Jiaheng Fang³, Sinan Xu³, Yufei Gao³, Xin Chen³, Xinbing Sui⁴, Guoxiong Li⁵

Affiliations

¹ The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China; Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou 310018, Zhejiang, China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou 310018, Zhejiang, China.
² Holistic Integrative Pharmacy Institutes and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China; Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou 310018, Zhejiang, China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou 310018, Zhejiang, China.
³ The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China.
⁴ The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China; Holistic Integrative Pharmacy Institutes and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China; Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou 310018, Zhejiang, China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou 310018, Zhejiang, China. Electronic address: hzzju@zju.edu.cn.
⁵ The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China. Electronic address: guoxiongli849@hotmail.com.

PMID: 32234642
DOI: 10.1016/j.biopha.2020.110108

Abstract

Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroptosis inhibitors to address inflammation.

Keywords: Anti-inflammatory; Ferroptosis; Inflammation.

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Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest.

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The emerging role of ferroptosis in inflammation

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The emerging role of ferroptosis in inflammation

Authors

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Conflict of interest statement

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