Episodic pulsatile secretion of FSH, LH, prolactin, oestradiol, oestrone, and LH circadian variations in polycystic ovary syndrome
- PMID: 3139335
- DOI: 10.1111/j.1365-2265.1988.tb01208.x
Episodic pulsatile secretion of FSH, LH, prolactin, oestradiol, oestrone, and LH circadian variations in polycystic ovary syndrome
Abstract
Pulsatile secretion of LH, FSH, PRL, oestradiol and oestrone was studied in a group of 16 patients with micropolycystic ovary syndrome (PCOS) and compared with that of normal ovulatory women in the fifth to sixth day of the cycle. Hormone concentrations were measured at 10 min intervals for 8 h starting at 0930 h. In seven subjects, the study was prolonged for 24 h, with 20 min interval samples, in an attempt to evaluate the circadian rhythm of LH by cosinor analysis. Significant fluctuations occurred in the concentration of each hormone. Values shown are mean +/- SD. PCOS subjects had high LH mean values (27.9 +/- 5.9 IU/l) (P less than 0.005). LH pulse amplitude was higher than controls (11.6 +/- 3.7 IU/l versus 5.2 +/- 1.8 IU/l; P less than 0.005) while no consistent changes in frequency or interpulse interval (62.0 +/- 10.7 min versus 65.8 +/- 19.2 min; P = NS) were found. A mean of 4.8 +/- 1.2 pulses of FSH occurred in 8 h and the mean pulse amplitude was 2.68 +/- 1.11 with no differences from controls. All patients were normoprolactinaemic. A mean of 5.5 +/- 1.9 pulses occurred in 8 h, the interpulse interval was 76.1 +/- 14.4 min and the amplitude was 2.87 +/- 0.76 ng/ml and there were no significant differences from controls; 75% of PRL pulses showed a temporal relationship with LH pulses. Oestrone mean basal values were higher in PCOS (47.2 +/- 12.5 pg/ml) than controls (32.0 +/- 9.9 pg/ml; P less than 0.02), while no differences were observed as regards oestradiol. Oestradiol pulse amplitude was nearly the same as oestrone (43.6 +/- 18.8 pg/ml and 37.7 +/- 16.1 pg/ml, respectively); 6.0 +/- 2.2 pulses and 6.0 +/- 1.6 pulses occurred in 8 h with an interpulse interval of 81.1 +/- 27.1 min and 71.8 +/- 11.1 min, respectively. Sixty-five per cent of LH pulses were followed by an oestradiol and oestrone peak. The mean time of the appearance was 17 +/- 15 min and 25 +/- 23 min, respectively. In the PCOS group a consistent 24 h rhythm in mean plasma LH levels was found with the highest hormone values at 1720 h (P less than 0.05) unrelated to apparent sleep and different from that of adult women. Pulse frequency showed a significant slowing during the night with the longest interpulse interval at 0327 h (P less than 0.03) while no significant periodicity was observed in LH pulse amplitude.(ABSTRACT TRUNCATED AT 400 WORDS)
Similar articles
-
Operating characteristics of the male hypothalamo-pituitary-gonadal axis: pulsatile release of testosterone and follicle-stimulating hormone and their temporal coupling with luteinizing hormone.J Clin Endocrinol Metab. 1987 Nov;65(5):929-41. doi: 10.1210/jcem-65-5-929. J Clin Endocrinol Metab. 1987. PMID: 3117834
-
Opioidergic regulation of LH pulsatility in women with polycystic ovary syndrome.Clin Endocrinol (Oxf). 1989 Feb;30(2):177-84. doi: 10.1111/j.1365-2265.1989.tb03739.x. Clin Endocrinol (Oxf). 1989. PMID: 2532984
-
The gonadotrophin surge in humans: its mechanism and role in ovulatory function--a review.Ann Acad Med Singap. 1990 Jul;19(4):524-9. Ann Acad Med Singap. 1990. PMID: 2221813 Review.
-
Reduction of gonadotropin-releasing hormone pulse frequency is associated with subsequent selective follicle-stimulating hormone secretion in women with polycystic ovarian disease.J Clin Endocrinol Metab. 1991 Jun;72(6):1278-85. doi: 10.1210/jcem-72-6-1278. J Clin Endocrinol Metab. 1991. PMID: 1902845
-
Neuroendocrine control in polycystic ovary-like syndrome.Gynecol Endocrinol. 1991 Dec;5(4):277-88. doi: 10.3109/09513599109028449. Gynecol Endocrinol. 1991. PMID: 1796749 Review.
Cited by
-
Prolactin in Polycystic Ovary Syndrome: Metabolic Effects and Therapeutic Prospects.Life (Basel). 2023 Oct 26;13(11):2124. doi: 10.3390/life13112124. Life (Basel). 2023. PMID: 38004264 Free PMC article. Review.
-
Ovulation induction techniques in women with polycystic ovary syndrome.Front Med (Lausanne). 2022 Aug 12;9:982230. doi: 10.3389/fmed.2022.982230. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36035398 Free PMC article. Review.
-
PCOS and Hyperprolactinemia: what do we know in 2019?Clin Med Insights Reprod Health. 2019 Sep 9;13:1179558119871921. doi: 10.1177/1179558119871921. eCollection 2019. Clin Med Insights Reprod Health. 2019. PMID: 31523136 Free PMC article. Review.
-
Endogenous Circadian Regulation of Female Reproductive Hormones.J Clin Endocrinol Metab. 2019 Dec 1;104(12):6049-6059. doi: 10.1210/jc.2019-00803. J Clin Endocrinol Metab. 2019. PMID: 31415086 Free PMC article.
-
Evidence for a Coupled Oscillator Model of Endocrine Ultradian Rhythms.J Biol Rhythms. 2018 Oct;33(5):475-496. doi: 10.1177/0748730418791423. Epub 2018 Aug 22. J Biol Rhythms. 2018. PMID: 30132387 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous