Associations Between Drinking and Cortical Thickness in Younger Adult Drinkers: Findings From the Human Connectome Project
- PMID: 31365137
- PMCID: PMC6721970
- DOI: 10.1111/acer.14147
Associations Between Drinking and Cortical Thickness in Younger Adult Drinkers: Findings From the Human Connectome Project
Abstract
Background: Previous neuroimaging studies examining relations between alcohol misuse and cortical thickness have revealed that increased drinking quantity and alcohol-related problems are associated with thinner cortex. Although conflicting regional effects are often observed, associations are generally localized to frontal regions (e.g., dorsolateral prefrontal cortex [DLPFC], inferior frontal gyrus [IFG], and anterior cingulate cortex). Inconsistent findings may be attributed to methodological differences, modest sample sizes, and limited consideration of sex differences.
Methods: This study examined neuroanatomical correlates of drinking quantity and heavy episodic drinking in a large sample of younger adults (N = 706; Mage = 28.8; 51% female) using magnetic resonance imaging data from the Human Connectome Project. Exploratory analyses examined neuroanatomical correlates of executive function (flanker task) and working memory (list sorting).
Results: Hierarchical linear regression models (controlling for age, sex, education, income, smoking, drug use, twin status, and intracranial volume) revealed significant inverse associations between drinks in past week and frequency of heavy drinking and cortical thickness in a majority of regions examined. The largest effect sizes were found for frontal regions (DLPFC, IFG, and the precentral gyrus). Follow-up regression models revealed that the left DLPFC was uniquely associated with both drinking variables. Sex differences were also observed, with significant effects largely specific to men.
Conclusions: This study adds to the understanding of brain correlates of alcohol use in a large, gender-balanced sample of younger adults. Although the cross-sectional methodology precludes causal inferences, these findings provide a foundation for rigorous hypothesis testing in future longitudinal investigations.
Keywords: Alcohol; Cortical Thickness; Dorsolateral Prefrontal Cortex; Heavy Drinking; Human Connectome Project; Neuroanatomy.
© 2019 by the Research Society on Alcoholism.
Figures
![Figure 1.](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6721970/bin/nihms-1040196-f0001.gif)
Similar articles
-
Age of onset of adolescent binge drinking is differentially associated with cortical thickness in post-9/11 adult Veterans.Alcohol Clin Exp Res. 2021 May;45(5):1065-1077. doi: 10.1111/acer.14606. Epub 2021 Apr 16. Alcohol Clin Exp Res. 2021. PMID: 33756020
-
Binge alcohol consumption in emerging adults: anterior cingulate cortical "thinness" is associated with alcohol use patterns.Alcohol Clin Exp Res. 2014 Jul;38(7):1955-64. doi: 10.1111/acer.12475. Epub 2014 Jun 24. Alcohol Clin Exp Res. 2014. PMID: 24961871 Free PMC article.
-
Interactive effects of baseline executive functioning and working memory depletion on alcohol use among heavy drinking young adults.Exp Clin Psychopharmacol. 2018 Aug;26(4):341-346. doi: 10.1037/pha0000205. Epub 2018 May 21. Exp Clin Psychopharmacol. 2018. PMID: 29781640
-
The Burden of Binge and Heavy Drinking on the Brain: Effects on Adolescent and Young Adult Neural Structure and Function.Front Psychol. 2017 Jun 30;8:1111. doi: 10.3389/fpsyg.2017.01111. eCollection 2017. Front Psychol. 2017. PMID: 28713313 Free PMC article. Review.
-
Adolescent cortical thickness pre- and post marijuana and alcohol initiation.Neurotoxicol Teratol. 2016 Sep-Oct;57:20-29. doi: 10.1016/j.ntt.2016.09.005. Epub 2016 Sep 26. Neurotoxicol Teratol. 2016. PMID: 27687470 Free PMC article. Review.
Cited by
-
Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.Addict Biol. 2024 Feb;29(2):e13365. doi: 10.1111/adb.13365. Addict Biol. 2024. PMID: 38380706 Free PMC article.
-
To Each His Own Fear: Gender-Related Association of Anxiety, Substance Use, and Eating Disorders in a Representative Birth Cohort Sample of Young Adults with Either COMT Val158Met allele.Neuropsychobiology. 2024;83(1):41-48. doi: 10.1159/000535912. Epub 2024 Jan 16. Neuropsychobiology. 2024. PMID: 38228118 Free PMC article.
-
Brain structural covariance network features are robust markers of early heavy alcohol use.Addiction. 2024 Jan;119(1):113-124. doi: 10.1111/add.16330. Epub 2023 Sep 19. Addiction. 2024. PMID: 37724052 Free PMC article.
-
The Effects of Alcohol and Cannabis Co-Use on Neurocognitive Function, Brain Structure, and Brain Function.Curr Behav Neurosci Rep. 2021 Dec;8(4):134-149. doi: 10.1007/s40473-021-00243-8. Epub 2021 Nov 18. Curr Behav Neurosci Rep. 2021. PMID: 36908333 Free PMC article.
-
Intracortical myelin in individuals with alcohol use disorder: An initial proof-of-concept study.Brain Behav. 2022 Oct;12(10):e2762. doi: 10.1002/brb3.2762. Epub 2022 Sep 14. Brain Behav. 2022. PMID: 36102109 Free PMC article.
References
-
- Barch DM, Burgess GC, Harms MP, Petersen SE, Schlaggar BL, Corbetta M, Glasser MF, Curtiss S, Dixit S, Feldt C, Nolan D, Bryant E, Hartley T, Footer O, Bjork JM, Poldrack R, Smith S, Johansen-Berg H, Snyder AZ, Van Essen DC, & WU-Minn HCP Consortium. (2013). Function in the human connectome: Task-fMRI and individual differences in behavior. NeuroImage, 80, 169–189. 10.1016/j.neuroimage.2013.05.033 - DOI - PMC - PubMed
-
- Benjamini Y, & Hochberg Y (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological), 57(1), 289–300.
-
- Boggio PS, Sultani N, Fecteau S, Merabet L, Mecca T, Pascual-Leone A, Basaglia A, & Fregni F (2008). Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: A double-blind, sham-controlled study. Drug and Alcohol Dependence, 92(1–3), 55–60. 10.1016/j.drugalcdep.2007.06.011 - DOI - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous