The complexity of tau in Alzheimer's disease
- PMID: 31028844
- PMCID: PMC7060758
- DOI: 10.1016/j.neulet.2019.04.022
The complexity of tau in Alzheimer's disease
Abstract
Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain, amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) peptides and hyperphosphorylated tau, respectively. Although accumulation of toxic Aβ species in the brain has been proposed as one of the important early events in AD, continued lack of success of clinical trials based on Aβ-targeting drugs has triggered the field to seek out alternative disease mechanisms and related therapeutic strategies. One of the new approaches is to uncover novel roles of pathological tau during disease progression. This review will primarily focus on recent advances in understanding the contributions of tau to AD.
Keywords: Acetylation; Alzheimer's disease; Glia; Neurodegeneration; Neuroinflammation; Phosphorylation; Synaptic dysfunction; Tau; Tau aggregation and propagation; Tauopathies.
Copyright © 2019 Elsevier B.V. All rights reserved.
Figures
![Fig. 1.](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/7060758/bin/nihms-1560337-f0001.gif)
![Fig. 2.](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/7060758/bin/nihms-1560337-f0002.gif)
Similar articles
-
Tau Proteins and Tauopathies in Alzheimer's Disease.Cell Mol Neurobiol. 2018 Jul;38(5):965-980. doi: 10.1007/s10571-017-0574-1. Epub 2018 Jan 3. Cell Mol Neurobiol. 2018. PMID: 29299792 Review.
-
Synaptic Mitochondria: An Early Target of Amyloid-β and Tau in Alzheimer's Disease.J Alzheimers Dis. 2021;84(4):1391-1414. doi: 10.3233/JAD-215139. J Alzheimers Dis. 2021. PMID: 34719499 Review.
-
Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation.J Neuroinflammation. 2023 Jul 14;20(1):165. doi: 10.1186/s12974-023-02853-3. J Neuroinflammation. 2023. PMID: 37452321 Free PMC article. Review.
-
A role for tau at the synapse in Alzheimer's disease pathogenesis.Neuropharmacology. 2014 Jan;76 Pt A:1-8. doi: 10.1016/j.neuropharm.2013.09.018. Epub 2013 Sep 25. Neuropharmacology. 2014. PMID: 24076336 Review.
-
Novel drugs affecting tau behavior in the treatment of Alzheimer's disease and tauopathies.Curr Alzheimer Res. 2011 Sep;8(6):678-85. doi: 10.2174/156720511796717122. Curr Alzheimer Res. 2011. PMID: 21605038 Review.
Cited by
-
The relationship between hypoxia and Alzheimer's disease: an updated review.Front Aging Neurosci. 2024 Jul 17;16:1402774. doi: 10.3389/fnagi.2024.1402774. eCollection 2024. Front Aging Neurosci. 2024. PMID: 39086755 Free PMC article. Review.
-
Lipoproteins and metabolites in diagnosing and predicting Alzheimer's disease using machine learning.Lipids Health Dis. 2024 May 21;23(1):152. doi: 10.1186/s12944-024-02141-w. Lipids Health Dis. 2024. PMID: 38773573 Free PMC article.
-
Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer's Disease.Int J Mol Sci. 2024 Apr 9;25(8):4165. doi: 10.3390/ijms25084165. Int J Mol Sci. 2024. PMID: 38673751 Free PMC article. Review.
-
Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye.Chem Sci. 2024 Mar 26;15(16):6053-6063. doi: 10.1039/d4sc00024b. eCollection 2024 Apr 24. Chem Sci. 2024. PMID: 38665526 Free PMC article.
-
DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and AppN-LF Mice and Influences Presymptomatic Pathology.Int J Mol Sci. 2024 Mar 23;25(7):3622. doi: 10.3390/ijms25073622. Int J Mol Sci. 2024. PMID: 38612434 Free PMC article.
References
-
- Alzheimer A, Uber eine eigenartige Erkrankung der Hirnrinde, Zentralbl. Nervenh. Psych 18 (1907) 177–179.
-
- Brion J, Passareiro H, Nunez J, Flament-Durand J, Mise en evidence immunologique de la proteine tau au niveau des lesions de degenerescence neurofibril-laire de la maladie d’Alzheimer, Arch. Biol. (Bruxelles) 95 (1985) 229–235.
-
- Lee VM, Balin BJ, Otvos L, Trojanowski JQ, A68: a major subunit of paired helical filaments and derivatized forms of normal Tau, Science 251 (1991) 675–678. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical