Reduction of serum testosterone levels during chronic glucocorticoid therapy
- PMID: 3083749
- DOI: 10.7326/0003-4819-104-5-648
Reduction of serum testosterone levels during chronic glucocorticoid therapy
Abstract
The effect of chronic glucocorticoid therapy on serum testosterone levels was studied in men aged 67 +/- 4 (SD) years with chronic pulmonary disease. The serum testosterone level was reduced in 14 of 16 patients to a mean value of 211 +/- 93 ng/dL, compared with 449 +/- 111 ng/dL in 11 age- and disease-matched control patients (p less than 0.001). The corticosteroid dosage and the serum testosterone level were inversely related (r = -0.78). Testosterone binding to serum proteins was not significantly affected. Basal gonadotrophin levels were not elevated while their secretory responses to exogenous gonadotrophin-releasing hormone (GnRH) were intact. We conclude that glucocorticoid therapy commonly reduces serum testosterone levels in older men due to alteration of hypothalamic GnRH secretion.
Similar articles
-
Age-related decrease in hypothalamic gonadotropin-releasing hormone (GnRH) gene expression, but not pituitary responsiveness to GnRH, in the male Brown Norway rat.J Androl. 2000 Jan-Feb;21(1):72-84. J Androl. 2000. PMID: 10670522
-
A study of the endocrine manifestations of hepatic cirrhosis.Q J Med. 1976 Jan;45(177):145-78. Q J Med. 1976. PMID: 769039
-
Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men.J Clin Endocrinol Metab. 2001 Feb;86(2):529-35. doi: 10.1210/jcem.86.2.7200. J Clin Endocrinol Metab. 2001. PMID: 11158004
-
Pituitary gonadotropin-releasing hormone (GnRH) receptor responses to GnRH in hypothalamus-lesioned rats: inhibition of responses by hyperprolactinemia and evidence that testosterone and estradiol modulate gonadotropin secretion at postreceptor sites.Endocrinology. 1984 Sep;115(3):1190-6. doi: 10.1210/endo-115-3-1190. Endocrinology. 1984. PMID: 6086288
-
Regulation of pituitary gonadotropin-releasing hormone receptors by pulsatile gonadotropin-releasing hormone injections in male rats. Modulation by testosterone.J Clin Invest. 1984 Sep;74(3):920-8. doi: 10.1172/JCI111510. J Clin Invest. 1984. PMID: 6088587 Free PMC article.
Cited by
-
Glucocorticoid-induced osteoporosis: an overview with focus on its prevention and management.Hormones (Athens). 2023 Dec;22(4):611-622. doi: 10.1007/s42000-023-00491-1. Epub 2023 Sep 27. Hormones (Athens). 2023. PMID: 37755658 Review.
-
New perspectives in functional hypogonadotropic hypogonadism: beyond late onset hypogonadism.Front Endocrinol (Lausanne). 2023 Jun 29;14:1184530. doi: 10.3389/fendo.2023.1184530. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37455902 Free PMC article. Review.
-
Relationship between Anthropometric, Physical and Hormonal Parameters among Pre-Pubertal Handball Players.Int J Environ Res Public Health. 2021 Sep 23;18(19):9977. doi: 10.3390/ijerph18199977. Int J Environ Res Public Health. 2021. PMID: 34639279 Free PMC article.
-
Acute anejaculation, hypogonadism, and fertility preservation in the setting of neurosarcoidosis: case report and literature review.F S Rep. 2020 Oct 8;1(3):317-325. doi: 10.1016/j.xfre.2020.09.014. eCollection 2020 Dec. F S Rep. 2020. PMID: 34223263 Free PMC article.
-
Erectile Dysfunction in Men with Chronic Obstructive Pulmonary Disease.J Clin Med. 2021 Jun 21;10(12):2730. doi: 10.3390/jcm10122730. J Clin Med. 2021. PMID: 34205713 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
