Smoking-induced changes in leptin serum levels and c/EBPalpha-related methylation status of the leptin core promotor during smoking cessation
- PMID: 30299257
- DOI: 10.1016/j.psyneuen.2018.09.022
Smoking-induced changes in leptin serum levels and c/EBPalpha-related methylation status of the leptin core promotor during smoking cessation
Abstract
Previous studies have provided evidence of an association between serum leptin levels and smoking as well as craving during smoking cessation. As promoter methylation also regulates leptin expression, we investigated the leptin gene promoter region of smokers before and after smoking cessation. Since leptin's core promoter region contains an essential c/EBPalpha transcription binding site, we narrowed our investigation to C-300 (-300 base pairs from the transcription start site) of that binding site. Female smokers showed hypermethylation of C-300 compared to non-smokers. Global methylation status is associated with higher craving and the degree of dependence in female smokers. Serum leptin levels in female smokers were significantly higher than in non-smokers. These findings support previous results and, for the first time, point to a pathophysiological role of c/EBPalpha-related C-300 methylation in tobacco dependence.
Keywords: Craving; Epigenetics; Leptin; Tobacco dependence.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Similar articles
-
DNA methylation of the LEP gene is associated with craving during alcohol withdrawal.Psychoneuroendocrinology. 2015 Jan;51:371-7. doi: 10.1016/j.psyneuen.2014.10.014. Epub 2014 Oct 23. Psychoneuroendocrinology. 2015. PMID: 25462909
-
Smoking and Promoter-Specific Deoxyribonucleic Acid Methylation of the Atrial Natriuretic Peptide Gene: Methylation of Smokers and Non-Smokers Differs Significantly during Withdrawal.Eur Addict Res. 2017;23(6):306-311. doi: 10.1159/000486279. Epub 2018 Jan 16. Eur Addict Res. 2017. PMID: 29339652
-
Patterns of DNA Methylation Across the Leptin Core Promoter in Four Diverse Asian and North American Populations.Hum Biol. 2016 Apr;88(2):121-135. doi: 10.13110/humanbiology.88.2.0121. Hum Biol. 2016. PMID: 28161997
-
Changes in circulating leptin levels during acute stress and associations with craving in abstinent smokers: a preliminary investigation.Psychoneuroendocrinology. 2014 Sep;47:232-40. doi: 10.1016/j.psyneuen.2014.05.008. Epub 2014 May 23. Psychoneuroendocrinology. 2014. PMID: 24954303 Free PMC article.
-
[Effects of physical activity on tobacco craving for smoking cessation].Rev Mal Respir. 2016 Jun;33(6):431-43. doi: 10.1016/j.rmr.2015.09.009. Epub 2016 Feb 3. Rev Mal Respir. 2016. PMID: 26852188 Review. French.
Cited by
-
Methylation of the Oxytocin, Oxytocin Receptor, and Vasopressin Gene Promoters in Tobacco Use Disorder during Cessation.Neuropsychobiology. 2024;83(1):28-40. doi: 10.1159/000535663. Epub 2024 Jan 5. Neuropsychobiology. 2024. PMID: 38185116 Free PMC article.
-
The Effect of Smoking Cessation on Body Weight and Other Metabolic Parameters with Focus on People with Type 2 Diabetes Mellitus.Int J Environ Res Public Health. 2022 Oct 14;19(20):13222. doi: 10.3390/ijerph192013222. Int J Environ Res Public Health. 2022. PMID: 36293800 Free PMC article. Review.
-
Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids.Metabolites. 2022 Aug 9;12(8):735. doi: 10.3390/metabo12080735. Metabolites. 2022. PMID: 36005607 Free PMC article.
-
Leptin promoter methylation in female patients with painful multisomatoform disorder and chronic widespread pain.Clin Epigenetics. 2022 Jan 21;14(1):13. doi: 10.1186/s13148-022-01235-5. Clin Epigenetics. 2022. PMID: 35063029 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials