Effect of long-term lifestyle intervention on mild cognitive impairment in hypertensive occupational population in China
- PMID: 30142828
- PMCID: PMC6113023
- DOI: 10.1097/MD.0000000000011975
Effect of long-term lifestyle intervention on mild cognitive impairment in hypertensive occupational population in China
Abstract
Background: The incidence of hypertension in China is high, which seriously affects people's health, including occupational population in mining areas. Cognitive dysfunction has a serious impact on the work and life of patients. Lifestyle intervention can improve diabetes and cardiovascular diseases. However, there are few studies on the effects of lifestyle interventions on cognitive function in hypertensive patients. So the aim of this study was to analyze the effect of long-term lifestyle intervention on mild cognitive impairment in hypertensive occupational population in China.
Methods: In September 2013, a cluster sampling was conducted for the workers in the Shaanxi Jinduicheng (intervention group) and Hancheng (control group) mining areas. In both groups, according to the blood pressure (BP) level, they were divided into hypertension stage 1 to 3 subgroups; according to their age, they were divided into between 45 and 59 and under 45 years subgroups; and according to whether or not taking medicine, they were divided into Lifestyle intervention, Lifestyle intervention plus medication, Medication, and No lifestyle intervention nor medication subgroups. The intervention group received regular lifestyle intervention for 2 years, which included diet, smoke, drink, and exercise intervention. Mild cognitive impairment was measured by the Montreal Cognitive Assessment (MoCA). The arterial stiffness was measured by Omron Automatic Atherosclerosis Tester. We conducted BP measurement and MoCA questionnaire at baseline, 6, 12, and 24 months.
Results: We analyzed a total of 510 mine workers, whose average age was 45.6 ± 13.4 years old. With the increase of BP level, the MoCA scores decreased significantly both in control and lifestyle intervention groups (P < .05). There was no obvious difference between the hypertensive patients whose age was between 45 and 59 to those under 45 in MoCA scores (P > .05). After 2 years, the BP, total cholesterol, glucose, and brachial-ankle pulse wave velocity of the Lifestyle intervention subgroup and Lifestyle intervention plus medication subgroup decreased (P < .05), and the MoCA scores and ankle-brachial index increased (P < .05), and the latter improved more significantly. Compared with the No lifestyle intervention nor medication subgroup, the BP and MoCA scores had no obvious changes at 6 months (P > .05), but the BP decreased and the MoCA scores increased significantly in the Lifestyle intervention and Lifestyle intervention plus medication subgroups after 1 and 2 years of lifestyle intervention (P < .05).
Conclusion: Long-term lifestyle intervention can be used as adjunctive therapy to improve the BP and cognitive function of hypertensive occupational population in China.
Conflict of interest statement
The authors have no conflicts of interest to disclose.
Figures
Similar articles
-
Occupational therapy for cognitive impairment in stroke patients.Cochrane Database Syst Rev. 2022 Mar 29;3(3):CD006430. doi: 10.1002/14651858.CD006430.pub3. Cochrane Database Syst Rev. 2022. PMID: 35349186 Free PMC article. Review.
-
Association of brachial-ankle pulse wave velocity with cognitive impairment in peritoneal dialysis patients.Ren Fail. 2021 Dec;43(1):934-941. doi: 10.1080/0886022X.2021.1937221. Ren Fail. 2021. PMID: 34120562 Free PMC article.
-
Association between Ankle Brachial Index, Brachial-Ankle Pulse Wave Velocity, and Mild Cognitive Impairment in Patients with Acute Lacunar Infarction.Eur Neurol. 2020;83(2):147-153. doi: 10.1159/000504844. Epub 2020 Jun 22. Eur Neurol. 2020. PMID: 32570253
-
[Effects of early intervention training on cognitive impairment in critical patients].Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Mar;31(3):298-302. doi: 10.3760/cma.j.issn.2095-4352.2019.03.008. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019. PMID: 30914089 Clinical Trial. Chinese.
-
Arterial stiffness and cognitive impairment.J Neurol Sci. 2017 Sep 15;380:1-10. doi: 10.1016/j.jns.2017.06.018. Epub 2017 Jun 27. J Neurol Sci. 2017. PMID: 28870545 Review.
Cited by
-
Chanwuyi Lifestyle Medicine Program Improves Memory and Executive Functions of Older Adults With Mild Cognitive Impairment.Am J Alzheimers Dis Other Demen. 2024 Jan-Dec;39:15333175241255744. doi: 10.1177/15333175241255744. Am J Alzheimers Dis Other Demen. 2024. PMID: 38764310 Free PMC article. Clinical Trial.
-
Associations of an individual's need for cognition with structural brain damage and cognitive functioning/impairment: cross-sectional population-based study.Br J Psychiatry. 2024 Jun;224(6):189-197. doi: 10.1192/bjp.2023.159. Br J Psychiatry. 2024. PMID: 38105553 Free PMC article.
-
Network pharmacology- and molecular docking-based analyses of the antihypertensive mechanism of Ilex kudingcha.Front Endocrinol (Lausanne). 2023 Aug 17;14:1216086. doi: 10.3389/fendo.2023.1216086. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37664830 Free PMC article.
-
Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging.Psychophysiology. 2023 Sep;60(9):e14306. doi: 10.1111/psyp.14306. Epub 2023 Apr 10. Psychophysiology. 2023. PMID: 37038273
-
Multi-domain interventions for the prevention of dementia and cognitive decline.Cochrane Database Syst Rev. 2021 Nov 8;11(11):CD013572. doi: 10.1002/14651858.CD013572.pub2. Cochrane Database Syst Rev. 2021. PMID: 34748207 Free PMC article. Review.
References
-
- Weiwei Chen, Runlin Gao, Lisheng Liu, et al. The summary of China Cardiovascular Disease Report 2016. Chin J Circ 2017;32:521–30.
-
- Hebert LE, Scherr PA, Bienias JL, et al. Alzheimer disease in the U.S. population: prevalence estimates using the 2000 census. JAMA Neurol 2003;60:1119–22. - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical