. 2018 May 29;90(22):e1979-e1988.

doi: 10.1212/WNL.0000000000005607. Epub 2018 Apr 27.

Pattern of polyphenol intake and the long-term risk of dementia in older persons

Sophie Lefèvre-Arbogast¹, David Gaudout², Julien Bensalem², Luc Letenneur², Jean-François Dartigues², Boris P Hejblum², Catherine Féart², Cécile Delcourt², Cécilia Samieri²

Affiliations

¹ From the University of Bordeaux, Inserm (S.L.-A., L.L., J.-F.D., B.P.H., C.F., C.D., C.S.), ISPED, Bordeaux Population Health Research Center, UMR 1219 Bordeaux, France; Activ'Inside (D.G., J.B.), Beychac et Caillau, France; Inria SISTM (B.P.H.), Bordeaux, France; and Department of Biostatistics (B.P.H.)., Harvard T.H. Chan School of Public Health, Boston, MA. Sophie.Lefevre-Arbogast@u-bordeaux.fr.
² From the University of Bordeaux, Inserm (S.L.-A., L.L., J.-F.D., B.P.H., C.F., C.D., C.S.), ISPED, Bordeaux Population Health Research Center, UMR 1219 Bordeaux, France; Activ'Inside (D.G., J.B.), Beychac et Caillau, France; Inria SISTM (B.P.H.), Bordeaux, France; and Department of Biostatistics (B.P.H.)., Harvard T.H. Chan School of Public Health, Boston, MA.

PMID: 29703769
DOI: 10.1212/WNL.0000000000005607

Free article

Pattern of polyphenol intake and the long-term risk of dementia in older persons

Sophie Lefèvre-Arbogast et al. Neurology. 2018.

Free article

. 2018 May 29;90(22):e1979-e1988.

doi: 10.1212/WNL.0000000000005607. Epub 2018 Apr 27.

Authors

Sophie Lefèvre-Arbogast¹, David Gaudout², Julien Bensalem², Luc Letenneur², Jean-François Dartigues², Boris P Hejblum², Catherine Féart², Cécile Delcourt², Cécilia Samieri²

Affiliations

¹ From the University of Bordeaux, Inserm (S.L.-A., L.L., J.-F.D., B.P.H., C.F., C.D., C.S.), ISPED, Bordeaux Population Health Research Center, UMR 1219 Bordeaux, France; Activ'Inside (D.G., J.B.), Beychac et Caillau, France; Inria SISTM (B.P.H.), Bordeaux, France; and Department of Biostatistics (B.P.H.)., Harvard T.H. Chan School of Public Health, Boston, MA. Sophie.Lefevre-Arbogast@u-bordeaux.fr.
² From the University of Bordeaux, Inserm (S.L.-A., L.L., J.-F.D., B.P.H., C.F., C.D., C.S.), ISPED, Bordeaux Population Health Research Center, UMR 1219 Bordeaux, France; Activ'Inside (D.G., J.B.), Beychac et Caillau, France; Inria SISTM (B.P.H.), Bordeaux, France; and Department of Biostatistics (B.P.H.)., Harvard T.H. Chan School of Public Health, Boston, MA.

PMID: 29703769
DOI: 10.1212/WNL.0000000000005607

Abstract

Objective: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study.

Methods: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk.

Results: The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend <0.01) in multivariate models.

Conclusions: In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.

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Reader response: Pattern of polyphenol intake and the long-term risk of dementia in older persons.
Brenner SR. Brenner SR. Neurology. 2019 Mar 5;92(10):493. doi: 10.1212/WNL.0000000000007028. Neurology. 2019. PMID: 30833476 No abstract available.

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Pattern of polyphenol intake and the long-term risk of dementia in older persons

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Pattern of polyphenol intake and the long-term risk of dementia in older persons

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