Association of prolonged QTc interval with Takotsubo cardiomyopathy: A neurocardiac syndrome inside the mystery of the insula of Reil
- PMID: 29663451
- PMCID: PMC6490097
- DOI: 10.1002/clc.22910
Association of prolonged QTc interval with Takotsubo cardiomyopathy: A neurocardiac syndrome inside the mystery of the insula of Reil
Abstract
The Takotsubo cardiomyopathy is often considered autochthonous to the heart, although the primary problem may be not in the heart muscle itself. Instead, similar to several Takotsubo-like cardiac pathologies seen in acute neurological diseases, it may reflect the capacity of the nervous system to injure the heart. Persuasive evidence exists that shocking emotional stress promotes direct heart injuries. Moreover, clinical and laboratory research shows that cardiac structural damage can occur in the presence of a normal heart, especially in the context of seizures, stroke, and traumatic brain injury or under conditions of psychological stress. The aim of this review is to summarize the clinical implications of these observations, several of which focus on the pivotal role of the insula of Reil in the brain-heart connection, to unravel the mystery of Takotsubo cardiomyopathy pathogenesis.
Keywords: Insula of Reil; QTc Interval; Takotsubo Cardiomyopathy; Ventricular Repolarization.
© 2018 Wiley Periodicals, Inc.
Conflict of interest statement
The authors declare no potential conflicts of interest.
Figures
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Comment in
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Brain-heart pathway to injury in takotsubo syndrome.Clin Cardiol. 2018 Jul;41(7):883. doi: 10.1002/clc.22970. Epub 2018 Jun 6. Clin Cardiol. 2018. PMID: 29696672 Free PMC article. No abstract available.
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QTc interval in takotsubo cardiomyopathy: How the activation of insular cortex interacts.Clin Cardiol. 2018 Jul;41(7):885. doi: 10.1002/clc.22976. Epub 2018 Jul 17. Clin Cardiol. 2018. PMID: 29766526 Free PMC article. No abstract available.
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Response to Association of Prolonged QTc Interval With Takotsubo Cardiomyopathy: A Neurocardiac Syndrome Inside the Mystery of the Insula of Reil.Clin Cardiol. 2018 Jul;41(7):884. doi: 10.1002/clc.22983. Epub 2018 Jul 18. Clin Cardiol. 2018. PMID: 29802727 Free PMC article. No abstract available.
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Insular cortex lesions are not the only culprit in Takotsubo syndrome.Clin Cardiol. 2018 Nov;41(11):1407-1408. doi: 10.1002/clc.23044. Epub 2018 Nov 19. Clin Cardiol. 2018. PMID: 30098032 Free PMC article. No abstract available.
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Response to Association of Prolonged QTc Interval With Takotsubo Cardiomyopathy: A Neurocardiac Syndrome Inside the Mystery of the Insula of Reil.Clin Cardiol. 2018 Nov;41(11):1409-1410. doi: 10.1002/clc.23045. Epub 2018 Nov 19. Clin Cardiol. 2018. PMID: 30098036 Free PMC article. No abstract available.
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