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Review
. 2018 Feb 28;19(3):694.
doi: 10.3390/ijms19030694.

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

María-Teresa García-Conesa  1 , Karen Chambers  2 , Emilie Combet  3 , Paula Pinto  4   5 , Mar Garcia-Aloy  6   7 , Cristina Andrés-Lacueva  8   9 , Sonia de Pascual-Teresa  10 , Pedro Mena  11 , Alekxandra Konic Ristic  12   13 , Wendy J Hollands  14 , Paul A Kroon  15 , Ana Rodríguez-Mateos  16 , Geoffrey Istas  17 , Christos A Kontogiorgis  18 , Dilip K Rai  19 , Eileen R Gibney  20 , Christine Morand  21 , Juan Carlos Espín  22 , Antonio González-Sarrías  23
Affiliations
Review

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

María-Teresa García-Conesa et al. Int J Mol Sci. .

Abstract

Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.

Keywords: anthocyanins; berries; cardiometabolic disorders; ellagitannins; interindividual variability; meta-analysis; nuts; pomegranate; red grapes; red wine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram showing the study selection process.
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