Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2017 Dec 18;12(12):e0189858.
doi: 10.1371/journal.pone.0189858. eCollection 2017.

A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)

Valentina Cannone  1   2 , Christopher G Scott  3 , Paul A Decker  3 , Nicholas B Larson  3 , Walter Palmas  4 , Kent D Taylor  5 , Thomas J Wang  6 , Deepak K Gupta  6 , Suzette J Bielinski  3 , John C Burnett Jr  1
Affiliations
Multicenter Study

A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)

Valentina Cannone et al. PLoS One. .

Abstract

In whites, the minor G allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with higher circulating levels of ANP and B-type natriuretic peptide (BNP), lower risk of hypertension, higher high-density lipoprotein (HDL) cholesterol plasma levels, and lower prevalence of obesity and metabolic syndrome. The observed phenotype is consistent with the blood pressure lowering and metabolic properties of ANP and BNP. The cardiovascular and metabolic phenotype associated with rs5068 genotypes in African Americans is undefined. We genotyped 1631 African Americans in the Multi-Ethnic Study of Atherosclerosis (MESA) for rs5068 and investigated their phenotype. Genotype frequencies of rs5068 were 93.2% AA (n = 1520), 6.7% AG (n = 110) and 0.1% GG (n = 1). All subsequent analyses are AG + GG versus AA genotype. Using a Bonferroni corrected level of significance of 0.005, the prevalence of metabolic syndrome (23% vs 38%, age-sex-adjusted p = 0.002) and triglycerides plasma values (76 vs 90 mg/dl, age-sex-BMI adjusted p = 0.004) were both significantly lower in the AG+GG genotypes. In the AG+GG genotypes, the prevalence of diabetes (8% vs 18%, age-sex-BMI-adjusted p = 0.02) and insulin plasma levels tended to be lower (4.8 vs 5.7 μU/ml, age-sex-BMI adjusted p = 0.04) whereas HDL-cholesterol levels tended to be higher (55 vs 50 mg/dl, age-sex-BMI-adjusted p = 0.04). No association was found with hypertension. The association between the rs5068 G allele and a favorable metabolic phenotype is now shown in African Americans. The rs5068 AG+GG genotypes are associated with lower prevalence of metabolic syndrome and lower triglycerides values.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Metabolic phenotype according to rs5068 genotypes.
A. Prevalence of Metabolic Syndrome. P value obtained from regression analysis adjusted for age and sex. B. Triglycerides Plasma Levels. P value obtained from regression analysis adjusted for age, sex and body mass index in a subgroup of subjects not taking lipid-lowering therapy (n = 1370). Values are median, first and third quartile. C. Prevalence of Diabetes Mellitus. P value obtained from regression analysis adjusted for age, sex and body mass index. D. HDL Cholesterol Plasma Levels. P value obtained from regression analysis adjusted for age, sex and body mass index in a subgroup of subjects not taking lipid-lowering therapy (n = 1370). Values are median, first and third quartile. High-density lipoprotein (HDL). E. Insulin Plasma Levels. P value obtained from regression analysis adjusted for age, sex and body mass index in a subgroup of subjects free of diabetes mellitus (AA = 1247, AG+GG = 102). Values are median, first and third quartile.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Garbers DL, Chrisman TD, Wiegn P, Katafuchi T, Albanesi JP, Bielinski V, et al. Membrane guanylyl cyclase receptors: an update. Trends Endocrinol Metab. 2006;17(6):251–8. Epub 2006/07/04. doi: 10.1016/j.tem.2006.06.006 - DOI - PMC - PubMed
    1. Miyashita K, Itoh H, Tsujimoto H, Tamura N, Fukunaga Y, Sone M, et al. Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity. Diabetes. 2009;58(12):2880–92. doi: 10.2337/db09-0393 . - DOI - PMC - PubMed
    1. Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessi-Fulgheri P, Zhang C, et al. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest. 2012;122(3):1022–36. Epub 2012/02/07. doi: 10.1172/JCI59701 . - DOI - PMC - PubMed
    1. Bordicchia M, Ceresiani M, Pavani M, Minardi D, Polito M, Wabitsch M, et al. Insulin/glucose induces natriuretic peptide clearance receptor in human adipocytes: a metabolic link with the cardiac natriuretic pathway. American journal of physiology Regulatory, integrative and comparative physiology. 2016;311(1):R104–14. Epub 2016/04/22. doi: 10.1152/ajpregu.00499.2015 . - DOI - PubMed
    1. Newton-Cheh C, Larson MG, Vasan RS, Levy D, Bloch KD, Surti A, et al. Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet. 2009;41(3):348–53. Epub 2009/02/17. doi: 10.1038/ng.328 - DOI - PMC - PubMed

Publication types

MeSH terms