The dopamine motive system: implications for drug and food addiction
- PMID: 29142296
- DOI: 10.1038/nrn.2017.130
The dopamine motive system: implications for drug and food addiction
Abstract
Behaviours such as eating, copulating, defending oneself or taking addictive drugs begin with a motivation to initiate the behaviour. Both this motivational drive and the behaviours that follow are influenced by past and present experience with the reinforcing stimuli (such as drugs or energy-rich foods) that increase the likelihood and/or strength of the behavioural response (such as drug taking or overeating). At a cellular and circuit level, motivational drive is dependent on the concentration of extrasynaptic dopamine present in specific brain areas such as the striatum. Cues that predict a reinforcing stimulus also modulate extrasynaptic dopamine concentrations, energizing motivation. Repeated administration of the reinforcer (drugs, energy-rich foods) generates conditioned associations between the reinforcer and the predicting cues, which is accompanied by downregulated dopaminergic response to other incentives and downregulated capacity for top-down self-regulation, facilitating the emergence of impulsive and compulsive responses to food or drug cues. Thus, dopamine contributes to addiction and obesity through its differentiated roles in reinforcement, motivation and self-regulation, referred to here as the 'dopamine motive system', which, if compromised, can result in increased, habitual and inflexible responding. Thus, interventions to rebalance the dopamine motive system might have therapeutic potential for obesity and addiction.
Similar articles
-
Individual variation in the motivational and neurobiological effects of an opioid cue.Neuropsychopharmacology. 2015 Mar 13;40(5):1269-77. doi: 10.1038/npp.2014.314. Neuropsychopharmacology. 2015. PMID: 25425322 Free PMC article.
-
Dual roles of dopamine in food and drug seeking: the drive-reward paradox.Biol Psychiatry. 2013 May 1;73(9):819-26. doi: 10.1016/j.biopsych.2012.09.001. Epub 2012 Oct 5. Biol Psychiatry. 2013. PMID: 23044182 Free PMC article. Review.
-
Imbalanced decision hierarchy in addicts emerging from drug-hijacked dopamine spiraling circuit.PLoS One. 2013 Apr 24;8(4):e61489. doi: 10.1371/journal.pone.0061489. Print 2013. PLoS One. 2013. PMID: 23637842 Free PMC article.
-
Rewarding, reinforcing and incentive salient events involve orexigenic hypothalamic neuropeptides regulating mesolimbic dopaminergic neurotransmission.Eur J Pharm Sci. 2014 Jun 16;57:2-10. doi: 10.1016/j.ejps.2014.01.008. Epub 2014 Jan 25. Eur J Pharm Sci. 2014. PMID: 24472703 Review.
-
[Neurobiology of addiction].Rev Med Liege. 2013 May-Jun;68(5-6):211-7. Rev Med Liege. 2013. PMID: 23888566 French.
Cited by
-
Chronic social isolation affects feeding behavior of juvenile zebrafish (Danio rerio).PLoS One. 2024 Jul 26;19(7):e0307967. doi: 10.1371/journal.pone.0307967. eCollection 2024. PLoS One. 2024. PMID: 39058733 Free PMC article.
-
Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population.Nat Commun. 2024 May 28;15(1):4548. doi: 10.1038/s41467-024-48780-6. Nat Commun. 2024. PMID: 38806481 Free PMC article.
-
Dopamine Pharmacodynamics: New Insights.Int J Mol Sci. 2024 May 13;25(10):5293. doi: 10.3390/ijms25105293. Int J Mol Sci. 2024. PMID: 38791331 Free PMC article. Review.
-
Population-level insights into temporal interference for focused deep brain neuromodulation.Front Hum Neurosci. 2024 Apr 19;18:1308549. doi: 10.3389/fnhum.2024.1308549. eCollection 2024. Front Hum Neurosci. 2024. PMID: 38708141 Free PMC article.
-
Environmental enrichment enhances ethanol preference over social reward in male swiss mice: Involvement of oxytocin-dopamine interactions.Neuropharmacology. 2024 Aug 1;253:109971. doi: 10.1016/j.neuropharm.2024.109971. Epub 2024 May 4. Neuropharmacology. 2024. PMID: 38705568
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous