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Review
. 2017 Nov 15;8(6):793-803.
doi: 10.3945/an.117.017178. Print 2017 Nov.

Food Groups and Risk of Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

Lukas Schwingshackl  1 , Carolina Schwedhelm  1 , Georg Hoffmann  2 , Sven Knüppel  1 , Khalid Iqbal  1 , Violetta Andriolo  1 , Angela Bechthold  3 , Sabrina Schlesinger  4 , Heiner Boeing  1
Affiliations
Review

Food Groups and Risk of Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

Lukas Schwingshackl et al. Adv Nutr. .

Erratum in

Abstract

The aim of this systematic review and meta-analysis was to summarize the evidence on the relation of the intakes of 12 major food groups, including whole grains, refined grains, vegetables, fruits, nuts, legumes, eggs, dairy, fish, red meat, processed meat, and sugar-sweetened beverages (SSBs) with the risk of hypertension. PubMed, Scopus, and Web of Science were searched systematically until June 2017 for prospective studies having quantitatively investigated the above-mentioned foods. We conducted meta-analysis on the highest compared with the lowest intake categories and linear and nonlinear dose-response meta-analyses to analyze the association. Summary RRs and 95% CIs were estimated by using a random-effects model. Overall, 28 reports were included in the meta-analysis. An inverse association for the risk of hypertension was observed for 30 g whole grains/d (RR: 0.92; 95% CI: 0.87, 0.98), 100 g fruits/d (RR: 0.97; 95% CI: 0.96, 0.99), 28 g nuts/d (RR: 0.70; 95% CI: 0.45, 1.08), and 200 g dairy/d (RR: 0.95; 95% CI: 0.94, 0.97), whereas a positive association for 100 g red meat/d (RR: 1.14; 95% CI: 1.02, 1.28), 50 g processed meat/d (RR: 1.12; 95% CI: 1.00, 1.26), and 250 mL SSB/d (RR: 1.07; 95% CI: 1.04, 1.10) was seen in the linear dose-response meta-analysis. Indication for nonlinear relations of the intakes of whole grains, fruits, fish, and processed meats with the risk of hypertension was detected. In summary, this comprehensive dose-response meta-analysis of 28 reports identified optimal intakes of whole grains, fruits, nuts, legumes, dairy, red and processed meats, and SSBs related to the risk of hypertension. These findings need to be seen under the light of very-low to low quality of meta-evidence. However, the findings support the current dietary guidelines in the prevention of hypertension.

Keywords: diet; dose-response; food groups; hypertension; meta-analysis.

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Conflict of interest statement

Author disclosures: LS, CS, GH, SK, KI, VA, AB, SS, and HB, no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram illustrating the identification and selection of studies.
FIGURE 2
FIGURE 2
Nonlinear dose-response relation between daily intakes of whole grains (A) (P-nonlinearity < 0.01; n = 4 studies), refined grains (B) (P-nonlinearity = 0.11; n = 3 studies), vegetables (C) (P-nonlinearity = 0.25; n = 7 studies), fruits (D) (P-nonlinearity = 0.06; n = 6 studies), nuts (E) (P-nonlinearity = 0.40; n = 4 studies), legumes (F) (P-nonlinearity = 0.17; n = 5 studies), dairy (G) (P-nonlinearity = 0.22; n = 8 studies), fish (H) (P-nonlinearity < 0.01; n = 7 studies), red meat (I) (P-nonlinearity = 0.30; n = 7 studies), processed meat (J) (P-nonlinearity < 0.001; n = 4 studies), and sugar-sweetened beverages (K) (P-nonlinearity = 0.73; n = 4 studies) and the risk of hypertension.
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