Pancreatic Neuroendocrine Tumors: State-of-the-Art Diagnosis and Management
- PMID: 29083468
Pancreatic Neuroendocrine Tumors: State-of-the-Art Diagnosis and Management
Abstract
The incidence of pancreatic neuroendocrine tumors (PNETs) has significantly increased in recent years, although this may reflect better detection and improved diagnosis, in addition to a true increase in incidence. The majority of PNETs are nonfunctional; up to half of nonmetastatic PNETs will present incidentally, and 85% will develop metastases over their lifetime. Treatment of PNETs is largely dictated by their heterogeneous nature and usually indolent behavior. Surgery is a mainstay of treatment, both in early PNETs and in metastatic disease. In this review, we focus on the treatment of well-differentiated early and metastatic PNETs, emphasizing current controversies, recent advances in therapy, and the multidisciplinary approach required for optimal treatment.
Similar articles
-
Endoscopic diagnosis and treatment of pancreatic neuroendocrine tumors.J Clin Gastroenterol. 2014 Nov-Dec;48(10):837-44. doi: 10.1097/MCG.0000000000000152. J Clin Gastroenterol. 2014. PMID: 24828360 Review.
-
Surgical Management of Pancreatic Neuroendocrine Tumors.Surg Clin North Am. 2016 Dec;96(6):1447-1468. doi: 10.1016/j.suc.2016.07.002. Surg Clin North Am. 2016. PMID: 27865287 Review.
-
Therapy for metastatic pancreatic neuroendocrine tumors.Ann Transl Med. 2014 Jan;2(1):8. doi: 10.3978/j.issn.2305-5839.2013.03.01. Ann Transl Med. 2014. PMID: 25332984 Free PMC article. Review.
-
Nonfunctional Pancreatic Neuroendocrine Tumors: Advances in Diagnosis, Management, and Controversies.Int Surg. 2015 Jun;100(6):1089-97. doi: 10.9738/INTSURG-D-14-00204.1. Epub 2015 Jan 15. Int Surg. 2015. PMID: 25590518 Free PMC article. Review.
-
Pancreatic Neuroendocrine Tumors: an Update.Indian J Surg. 2015 Oct;77(5):395-402. doi: 10.1007/s12262-015-1360-2. Epub 2015 Oct 13. Indian J Surg. 2015. PMID: 26722203 Free PMC article.
Cited by
-
Deciphering pancreatic neuroendocrine tumors: Unveiling through circulating small extracellular vesicles.Heliyon. 2024 Apr 1;10(7):e29079. doi: 10.1016/j.heliyon.2024.e29079. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38596136 Free PMC article.
-
A Novel Observational Strategy for Nonfunctional Pancreatic Neuroendocrine Neoplasms With Texture Analysis: A Multicenter Retrospective Study.Cancer Diagn Progn. 2023 Sep 3;3(5):543-550. doi: 10.21873/cdp.10253. eCollection 2023 Sep-Oct. Cancer Diagn Progn. 2023. PMID: 37671308 Free PMC article.
-
Defining a New Classification System for the Surgical Management of Neuroendocrine Tumor Liver Metastases.J Clin Med. 2023 Mar 23;12(7):2456. doi: 10.3390/jcm12072456. J Clin Med. 2023. PMID: 37048539 Free PMC article. Review.
-
Risk Factors of Lymph Node Metastasis in Patients with Pancreatic Neuroendocrine Tumors (PNETs).Gastroenterol Res Pract. 2020 Sep 29;2020:1946156. doi: 10.1155/2020/1946156. eCollection 2020. Gastroenterol Res Pract. 2020. PMID: 33061957 Free PMC article.
-
Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia.Case Rep Endocrinol. 2020 Jan 31;2020:4239679. doi: 10.1155/2020/4239679. eCollection 2020. Case Rep Endocrinol. 2020. PMID: 32082648 Free PMC article.
Publication types
LinkOut - more resources
Full Text Sources
