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Meta-Analysis
. 2017 Nov;25(6):524-532.
doi: 10.1002/erv.2555.

Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies

Enrico Collantoni  1   2 , Marco Solmi  1   2 , Davide Gallicchio  1   2 , Paolo Santonastaso  1   2   3 , Paolo Meneguzzo  1   2 , Andrè F Carvalho  4 , Brendon Stubbs  5   6   7 , Maurizio Clementi  8 , Claudia Pinato  8 , Monica Forzan  8 , Matteo Cassina  8 , Francesca Fontana  2 , Ivana Piva  2 , Roberta Siani  2 , Pierandrea Salvo  2 , Elena Tenconi  1   2   3 , Nicola Veronese  9 , Christoph U Correll  10   11 , Angela Favaro  1   2   3
Affiliations
Meta-Analysis

Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies

Enrico Collantoni et al. Eur Eat Disord Rev. 2017 Nov.

Abstract

Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs).

Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls.

Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I2 = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I2 = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I2 = 0-44%).

Conclusions: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

Keywords: Val158Met; anorexia nervosa; bulimia nervosa; catechol-O-methyltransferase (COMT); polymorphism.

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