Muscle functions and bone strength are impaired in adolescents with type 1 diabetes
- PMID: 29017892
- DOI: 10.1016/j.bone.2017.10.005
Muscle functions and bone strength are impaired in adolescents with type 1 diabetes
Abstract
Background: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system.
Methods: Ninety-five children and adolescents (59 boys and 36 girls, mean age 16.2±1.2years) with T1D were included in this cross-sectional study. Study participants were divided into two groups according to the duration of the disease (<6years and >9years, respectively). Volumetric BMD of the non-dominant tibia was assessed using peripheral quantitative computed tomography (pQCT). Dynamic muscle function was evaluated using jumping mechanography. Gender- and height-specific Z-scores were calculated using published reference data. HbA1c was evaluated retrospectively as an average over the past 5years.
Results: Relative muscle power (Pmax/mass) and force (Fmax/body weight) were significantly decreased in T1D subjects (mean Z-scores -0.4±1.0; p<0.001, and -0.3±1.1; p<0.01, respectively). The duration of T1D negatively affected Pmax/mass (p<0.01) but not Fmax/body weight (p=0.54). Patients with T1D had also decreased trabecular BMD, the Strength-Strain Index and cortical thickness (mean Z-scores -0.8±1.3; -0.5±0.8 and -1.1±0.8, respectively, p<0.001 for all) whereas cortical BMD was increased when compared to controls (Z-score 1.2±0.90, p<0.001). No association was observed between the HbA1c and 25-hydroxyvitamin D levels and bone or muscle parameters.
Conclusion: T1D influences the musculoskeletal system in adolescence. Decreased muscle function could contribute to the osteoporosis reported in adult diabetic patients.
Keywords: Adolescence; Bone strength; Mechanography; Muscle function; Peripheral quantitative computed tomography; Type 1 diabetes.
Copyright © 2017 Elsevier Inc. All rights reserved.
Similar articles
-
Unaffected bone mineral density in Danish children and adolescents with type 1 diabetes.J Bone Miner Metab. 2020 May;38(3):328-337. doi: 10.1007/s00774-019-01058-0. Epub 2019 Nov 21. J Bone Miner Metab. 2020. PMID: 31754807
-
Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures.Eur J Pediatr. 2017 Oct;176(10):1355-1363. doi: 10.1007/s00431-017-2988-7. Epub 2017 Aug 24. Eur J Pediatr. 2017. PMID: 28840427
-
Bone Geometry, Volumetric Density, Microarchitecture, and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients With Type 1 Diabetes Mellitus.J Bone Miner Res. 2015 Dec;30(12):2188-99. doi: 10.1002/jbmr.2573. Epub 2015 Jul 20. J Bone Miner Res. 2015. PMID: 26096924
-
Bone health in type 1 diabetes: focus on evaluation and treatment in clinical practice.J Endocrinol Invest. 2015 Sep;38(9):941-50. doi: 10.1007/s40618-015-0284-9. Epub 2015 Apr 12. J Endocrinol Invest. 2015. PMID: 25863666 Review.
-
Peripheral quantitative computed tomography (pQCT) to assess bone health in children, adolescents, and young adults: a review of normative data.J Pediatr Hematol Oncol. 2013 Nov;35(8):581-9. doi: 10.1097/MPH.0000000000000017. J Pediatr Hematol Oncol. 2013. PMID: 24149583 Review.
Cited by
-
Prevalence of Sarcopenia and Dynapenia and Related Clinical Outcomes in Patients with Type 1 Diabetes Mellitus.Nutrients. 2023 Nov 24;15(23):4914. doi: 10.3390/nu15234914. Nutrients. 2023. PMID: 38068772 Free PMC article.
-
Pharmacologic Inhibition of Myostatin With a Myostatin Antibody Improves the Skeletal Muscle and Bone Phenotype of Male Insulin-Deficient Diabetic Mice.JBMR Plus. 2023 Oct 26;7(11):e10833. doi: 10.1002/jbm4.10833. eCollection 2023 Nov. JBMR Plus. 2023. PMID: 38025035 Free PMC article.
-
Catabolism of fats and branched-chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose.Endocrinol Diabetes Metab. 2023 Nov;6(6):e448. doi: 10.1002/edm2.448. Epub 2023 Sep 16. Endocrinol Diabetes Metab. 2023. PMID: 37715520 Free PMC article.
-
Assessment of Balance Parameters in Children with Weakened Axial Muscle Tone Undergoing Sensory Integration Therapy.Children (Basel). 2023 May 7;10(5):845. doi: 10.3390/children10050845. Children (Basel). 2023. PMID: 37238393 Free PMC article.
-
Increase of jump performance during GH treatment in short children born SGA.Front Endocrinol (Lausanne). 2023 Apr 18;14:1122287. doi: 10.3389/fendo.2023.1122287. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37143735 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous