Esr1+ cells in the ventromedial hypothalamus control female aggression
- PMID: 28920934
- PMCID: PMC5953764
- DOI: 10.1038/nn.4644
Esr1+ cells in the ventromedial hypothalamus control female aggression
Abstract
As an essential means of resolving conflicts, aggression is expressed by both sexes but often at a higher level in males than in females. Recent studies suggest that cells in the ventrolateral part of the ventromedial hypothalamus (VMHvl) that express estrogen receptor-α (Esr1) and progesterone receptor are essential for male but not female mouse aggression. In contrast, here we show that VMHvlEsr1+ cells are indispensable for female aggression. This population was active when females attacked naturally. Inactivation of these cells reduced female aggression whereas their activation elicited attack. Additionally, we found that female VMHvl contains two anatomically distinguishable subdivisions that showed differential gene expression, projection and activation patterns after mating and fighting. These results support an essential role of the VMHvl in both male and female aggression and reveal the existence of two previously unappreciated subdivisions in the female VMHvl that are involved in distinct social behaviors.
Conflict of interest statement
The authors declare no competing financial interests
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References
-
- Darwin C. The descent of man, and selection in relation to sex. D. Appleton and company; 1871.
-
- Kruk MR, et al. Discriminant analysis of the localization of aggression-inducing electrode placements in the hypothalamus of male rats. Brain Res. 1983;260:61–79. - PubMed
-
- Olivier B, Wiepkema PR. Behaviour changes in mice following electrolytic lesions in the median hypothalamus. Brain Res. 1974;65:521–524. - PubMed
-
- Siegel A, Roeling TAP, Gregg TR, Kruk MR. Neuropharmacology of brain-stimulation-evoked aggression. Neurosci Biobehav R. 1999;23:359–389. - PubMed
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