Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus
- PMID: 2891993
- DOI: 10.1016/s0140-6736(87)91128-7
Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus
Abstract
Of 37 pancreases removed at necropsy from patients with type 1 diabetes 34 had residual beta cells. In 33 of the 34 the beta cells were positive for immunoreactive alpha-interferon, and this finding in islets was related to hyperexpression of class I major histocompatibility complex (MHC) antigens. Of islets showing class I hyperexpression 93% contained alpha-interferon compared with 0.4% of those showing no hyperexpression. Among 80 control pancreases significant numbers of beta cells containing alpha-interferon were present only in 4 cases of acute infantile viral pancreatitis, known to be caused by Coxsackie-B viral infection in 3 cases. Chronic viral infection of beta cells may underlie the pathogenesis of some cases of type 1 diabetes.
Similar articles
-
Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus.Diabetologia. 1987 May;30(5):333-43. doi: 10.1007/BF00299027. Diabetologia. 1987. PMID: 3301484 Free PMC article.
-
The pathology of the endocrine pancreas in type 1 (insulin-dependent) diabetes mellitus.APMIS. 1996 Mar;104(3):161-7. doi: 10.1111/j.1699-0463.1996.tb00702.x. APMIS. 1996. PMID: 8611188 Review.
-
Pancreatic pathology in type 1 diabetes in human.Novartis Found Symp. 2008;292:2-13; discussion 13-8, 122-9, 202-3. Novartis Found Symp. 2008. PMID: 19203089
-
Coxsackie B4 infection and islet cell antibodies three years before overt diabetes.J Pediatr. 1982 Sep;101(3):398-400. doi: 10.1016/s0022-3476(82)80067-x. J Pediatr. 1982. PMID: 6286913 No abstract available.
-
C. L. Oakley lecture (1987). The pathogenesis of beta cell destruction in type I (insulin-dependent) diabetes mellitus.J Pathol. 1987 Jul;152(3):141-8. doi: 10.1002/path.1711520302. J Pathol. 1987. PMID: 3309229 Review.
Cited by
-
Interferons are key cytokines acting on pancreatic islets in type 1 diabetes.Diabetologia. 2024 May;67(5):908-927. doi: 10.1007/s00125-024-06106-7. Epub 2024 Feb 26. Diabetologia. 2024. PMID: 38409439
-
The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes.Front Endocrinol (Lausanne). 2023 Oct 6;14:1270325. doi: 10.3389/fendo.2023.1270325. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37867531 Free PMC article. Review.
-
Deucravacitinib, a tyrosine kinase 2 pseudokinase inhibitor, protects human EndoC-βH1 β-cells against proinflammatory insults.Front Immunol. 2023 Oct 3;14:1263926. doi: 10.3389/fimmu.2023.1263926. eCollection 2023. Front Immunol. 2023. PMID: 37854597 Free PMC article.
-
LncRNA ARGI Contributes to Virus-Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN-Stimulated Genes.Adv Sci (Weinh). 2023 Sep;10(25):e2300063. doi: 10.1002/advs.202300063. Epub 2023 Jun 29. Adv Sci (Weinh). 2023. PMID: 37382191 Free PMC article.
-
Vaccination prevents severe COVID-19 outcome in patients with neutralizing type 1 interferon autoantibodies.iScience. 2023 Jul 21;26(7):107084. doi: 10.1016/j.isci.2023.107084. Epub 2023 Jun 9. iScience. 2023. PMID: 37346050 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
