. 2017 Nov:85:42-48.

doi: 10.1016/j.psyneuen.2017.08.006. Epub 2017 Aug 5.

More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder

Tzu-Yun Wang¹, Sheng-Yu Lee², Ming-Chuan Hu³, Shiou-Lan Chen⁴, Yun-Hsuan Chang⁵, Chun-Hsien Chu⁶, Shih-Hsien Lin⁷, Chia-Ling Li¹, Liang-Jen Wang⁸, Po See Chen⁹, Shih-Heng Chen¹⁰, San-Yuan Huang¹¹, Nian-Sheng Tzeng¹², I Hui Lee⁹, Kao Chin Chen⁹, Yen Kuang Yang¹³, Jau-Shyong Hong¹⁰, Ru-Band Lu¹⁴

Affiliations

¹ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
² Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
³ Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan.
⁴ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁵ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychology, Asia University, Taichung, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
⁶ Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁷ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.
⁸ Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
⁹ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.
¹⁰ Neurobiology Laboratory, NIH/NIEHS, Research Triangle Park, NC, USA.
¹¹ Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
¹² Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Student Counseling Center, National Defense Medical Center, Taipei, Taiwan.
¹³ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.
¹⁴ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan. Electronic address: rblu@mail.ncku.edu.tw.

PMID: 28810156
DOI: 10.1016/j.psyneuen.2017.08.006

More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder

Tzu-Yun Wang et al. Psychoneuroendocrinology. 2017 Nov.

. 2017 Nov:85:42-48.

doi: 10.1016/j.psyneuen.2017.08.006. Epub 2017 Aug 5.

Authors

Affiliations

¹ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
² Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
³ Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan.
⁴ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁵ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychology, Asia University, Taichung, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
⁶ Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁷ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.
⁸ Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
⁹ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan.
¹⁰ Neurobiology Laboratory, NIH/NIEHS, Research Triangle Park, NC, USA.
¹¹ Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
¹² Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Student Counseling Center, National Defense Medical Center, Taipei, Taiwan.
¹³ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.
¹⁴ Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan. Electronic address: rblu@mail.ncku.edu.tw.

PMID: 28810156
DOI: 10.1016/j.psyneuen.2017.08.006

Erratum in

Corrigendum to "More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder" [Psychoneuroendocrinology (2017; 85, 42-48).
Wang TY, Lee SY, Hu MC, Chen SL, Chang YH, Chu CH, Lin SH, Li CL, Wang LJ, Chen PS, Chen SH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. Wang TY, et al. Psychoneuroendocrinology. 2021 Sep;131:105233. doi: 10.1016/j.psyneuen.2021.105233. Epub 2021 Jul 7. Psychoneuroendocrinology. 2021. PMID: 34243962 No abstract available.

Abstract

Antisocial personality disorder (ASPD) is highly comorbid with substance use disorders (SUDs). We hypothesize that chronic neuroinflammation and the loss of neurotrophic factors prompts the pathogenesis of both disorders. We used ELISA to measure plasma levels of proinflammatory (tumor necrosis factor-α [TNF-α], C-reactive protein [CRP]) and anti-inflammatory factors (transforming growth factor-β1 [TGF-β1] and interleukin-10 [IL-10]), and brain-derived neurotrophic factor (BDNF) in male patients with ASPD (n=74), SUDs (n=168), ASPD comorbid with SUDs (ASPD+SUDs) (n=438), and Healthy Controls (HCs) (n=81). A multivariate analysis of covariance (MANCOVA) controlled for possible confounders was used to compare cytokines and BDNF levels between groups. The results of MANCOVA adjusted for age showed a significant (p<0.001) main effect of diagnosis on inflammatory factors and BDNF expression in these groups. ASPD, SUDs, and ASPD+SUDs patients had significantly (p<0.001) higher TNF-α levels but lower TGF-β1 and BDNF levels. SUDs and ASPD+SUDs patients had higher IL-10 levels than did ASPD patients and HCs. There was no difference in IL-10 levels between HCs and ASPD. Moreover, subgrouping SUDs and ASPD±SUDs into opioid use disorder (OUD) and other SUDs groups showed that the IL-10 levels were specifically higher in OUD and ASPD±OUD groups than other SUDs (P≤0.001). We conclude that uncontrolled inflammation and losing neurotrophic factors, with or without comorbid SUDs, underlies ASPD. IL-10 expression might be more specifically associated with OUD.

Keywords: Antisocial personality disorder; Brain-derived neurotrophic factor; Cytokines; Opioid use disorder; Substance use disorders.

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More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder

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More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder

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