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. 2017 Jul;118(1):60-68.
doi: 10.1017/S0007114517001805. Epub 2017 Aug 11.

Dietary polyphenol intake and risk of type 2 diabetes in the Polish arm of the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study

Giuseppe Grosso  1 , Urszula Stepaniak  2 , Agnieszka Micek  2 , Magdalena Kozela  2 , Denes Stefler  3 , Martin Bobak  3 , Andrzej Pajak  2
Affiliations

Dietary polyphenol intake and risk of type 2 diabetes in the Polish arm of the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study

Giuseppe Grosso et al. Br J Nutr. 2017 Jul.

Abstract

This study aimed to test the association between dietary content of total and individual classes of polyphenols and incident cases of type 2 diabetes in Polish adults participating to the Health, Alcohol and Psychosocial factors In Eastern Europe study. At baseline, diet by 148-item FFQ and health information were collected from 5806 participants free of diabetes. Self-reported incident type 2 diabetes was ascertained at 2-4-year follow-up visit. OR and 95 % CI of type 2 diabetes comparing the various categories of polyphenol intake to the lowest one (reference category) and as 1 sd increase modelled as continuous variable were calculated by performing age-, energy-, and multivariate-adjusted logistic regression models. During the follow-up, 456 incident cases of type 2 diabetes occurred. When comparing extreme quartiles, intake of total polyphenol was inversely associated with the risk of type 2 diabetes (OR 0·43; 95 % CI 0·30, 0·61); 1 sd increase was associated with a reduced risk of diabetes (OR 0·68; 95 % CI 0·59, 0·79). Among the main classes of polyphenols, flavonoids, phenolic acids, and stilbenes were independent contributors to this association. Both subclasses of phenolic acids were associated with decreased risk of type 2 diabetes, whereas among subclasses of flavonoids, high intake of flavanols, flavanones, flavones and anthocyanins was significantly associated with decreased risk of type 2 diabetes. Total dietary polyphenols and some classes of dietary polyphenols were associated with lower risk of type 2 diabetes.

Keywords: Alcohol and Psychosocial factors in Eastern Europe; HAPIEE Health; Diabetes; Flavonoids; Lignans; Phenolic acids; Polyphenols; Prospective studies; Stilbenes.

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Figures

Fig. 1
Fig. 1
Association between total polyphenol intake and incidence of type 2 diabetes.
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