Inflammation: The Common Pathway of Stress-Related Diseases
- PMID: 28676747
- PMCID: PMC5476783
- DOI: 10.3389/fnhum.2017.00316
Inflammation: The Common Pathway of Stress-Related Diseases
Abstract
While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%-90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.
Keywords: cardiovascular disease; depression; inflammation; metabolic disease; neurodegenerative disease; neuroimmunomodulation; neurotransmitter; stress-related disease.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5476783/bin/fnhum-11-00316-g0001.gif)
Similar articles
-
The Relationship between Stress, Inflammation, and Depression.Biomedicines. 2022 Aug 9;10(8):1929. doi: 10.3390/biomedicines10081929. Biomedicines. 2022. PMID: 36009476 Free PMC article. Review.
-
Transcriptional Regulation in Non-Alcoholic Fatty Liver Disease.Metabolites. 2020 Jul 9;10(7):283. doi: 10.3390/metabo10070283. Metabolites. 2020. PMID: 32660130 Free PMC article. Review.
-
Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation.Eur J Sport Sci. 2019 Aug;19(7):994-1003. doi: 10.1080/17461391.2019.1571114. Epub 2019 Feb 8. Eur J Sport Sci. 2019. PMID: 30732555 Review.
-
Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases.Diabetes Metab J. 2017 Dec;41(6):430-437. doi: 10.4093/dmj.2017.41.6.430. Epub 2017 Nov 17. Diabetes Metab J. 2017. PMID: 29199410 Free PMC article. Review.
-
Homeostasis, inflammation, and disease susceptibility.Cell. 2015 Feb 26;160(5):816-827. doi: 10.1016/j.cell.2015.02.010. Cell. 2015. PMID: 25723161 Free PMC article. Review.
Cited by
-
Human immune and metabolic biomarker levels, and stress-biomarker associations, differ by season: Implications for biomedical health research.Brain Behav Immun Health. 2024 May 8;38:100793. doi: 10.1016/j.bbih.2024.100793. eCollection 2024 Jul. Brain Behav Immun Health. 2024. PMID: 38813082 Free PMC article.
-
Combination therapy is it in the future for successfully treating peripheral diabetic neuropathy?Front Endocrinol (Lausanne). 2024 May 15;15:1357859. doi: 10.3389/fendo.2024.1357859. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38812811 Free PMC article. Review.
-
Main Biological Models of Resilience.Clin Neuropsychiatry. 2024 Apr;21(2):115-134. doi: 10.36131/cnfioritieditore20240201. Clin Neuropsychiatry. 2024. PMID: 38807984 Free PMC article. Review.
-
Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease.Int J Mol Sci. 2024 May 7;25(10):5085. doi: 10.3390/ijms25105085. Int J Mol Sci. 2024. PMID: 38791125 Free PMC article. Review.
-
A comprehensive investigation on alleviating oxidative stress and inflammation in hyperglycaemic conditions through in vitro experiments and computational analysis.Saudi J Biol Sci. 2024 Jul;31(7):104003. doi: 10.1016/j.sjbs.2024.104003. Epub 2024 Apr 21. Saudi J Biol Sci. 2024. PMID: 38766504 Free PMC article.
References
-
- Angelo L. S., Talpaz M., Kurzrock R. (2002). Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53. Cancer Res. 62, 932–940. - PubMed
-
- Aparicio-Vergara M., Hommelberg P. P. H., Schreurs M., Gruben N., Stienstra R., Shiri-Sverdlov R., et al. . (2013). Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model. Hepatology 57, 566–576. 10.1002/hep.26046 - DOI - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources