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Comparative Study
. 2017 Jul;231(1):140-155.
doi: 10.1111/joa.12620. Epub 2017 May 23.

Osteoarthritis in two marine mammals and 22 land mammals: learning from skeletal remains

Korakot Nganvongpanit  1 , Ratsadakorn Soponteerakul  1 , Piyatida Kaewkumpai  1 , Veerasak Punyapornwithaya  2 , Kittisak Buddhachat  3 , Raksiri Nomsiri  4 , Patcharaporn Kaewmong  5 , Kongkiat Kittiwatanawong  5 , Rachanchai Chawangwongsanukun  6 , Taweepoke Angkawanish  7 , Chatchote Thitaram  8 , Pasuk Mahakkanukrauh  9   10
Affiliations
Comparative Study

Osteoarthritis in two marine mammals and 22 land mammals: learning from skeletal remains

Korakot Nganvongpanit et al. J Anat. 2017 Jul.

Abstract

The occurrence of osteoarthritis (OA) in marine mammals is still questionable. Here we investigated the prevalence of OA in marine (dolphin and dugong) and terrestrial mammals (Asian elephant, Asiatic buffalo, camel, cat, cattle, deer, dog, domestic goat, horse, human, hyena, impala, lion, Malayan tapir, Assam macaque, mule, pig, rabbit, red kangaroo, sheep, tiger and waterbuck). Skeletal remains obtained from five institutes were used as subjects; a total of 45 different parts (locations) of bones were observed for OA lesions. The prevalence of OA was reported as number of OA lesions/total number of bones. Our results revealed that the presence of OA in marine species (dolphin and dugong) was 2.44% and 3.33%, respectively. In dolphins, the highest OA occurrence was on the left and right humeral trochlea, with 13.68% and 12.63%, respectively, while the highest number of OA lesions in dugongs was on the lumbar vertebrae (8.79%). No significant difference (P > 0.05) in the prevalence of OA between sexes in dolphins and dugongs was observed, but we found a significant difference (P < 0.05) in 24 bone locations of human bones, which had the highest OA prevalence (48.93%), followed by dogs (3.94%). In conclusion, OA can occur in marine mammals, similar to terrestrial mammals, even though their natural habitat is the ocean.

Keywords: bone; degenerative joint disease; land mammal; marine mammal.

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Figures

Figure 1
Figure 1
Based on cytochrome b (CYTB), a phylogenetic tree was constructed using a neighbor‐joining model to illustrate the genetic relationship and osteoarthritis (OA) occurrence among species, including dog, cat, pig, buffalo, camel, cow, waterbuck, deer, goat, sheep, horse, hyena, impala, kangaroo, lion, tiger, rabbit, tapir, elephant, monkey, human, dugong and dolphin. Numbers are bootstrap values (in percent 1000 replications) of neighbor joining. + = OA occurrence; − = no OA lesions; and ? = species not determined for OA lesions. Green indicates the herbivore groups, and red indicates carnivores and omnivores.
Figure 2
Figure 2
Representative photos of the normal articular surface of canine acetabulum (A), osteophyte formation as a reference for osteoarthritis (OA) (B), and severe osteophyte formation with subchondral bone degradation as a reference for OA (C).
Figure 3
Figure 3
Representative photos of abnormal structures (arrows) such as pathological lesions from fracture (A), and bone degradation from the environment (B).
Figure 4
Figure 4
Osteoarthritis (OA) lesions (arrows) were found in dolphin bones at different locations, such as occipital condyle (A), glenoid cavity of scapula (B), head of humerus and carpal joint (C), and body of vertebrae (D and E).
Figure 5
Figure 5
Osteoarthritis (OA) lesions (arrows) were found in dugong bones at different locations, such as the occipital condyle (A), body of vertebrae (B–D), glenoid cavity of scapula (E), head of humerus (F) and styloid process of ulna/radius (G).
Figure 6
Figure 6
Representative photos showing osteoarthritis (OA) lesions (arrows) in carpal joint of Malayan tapir (A), acetabulum of tiger (B), elbow joint of sheep (C), articular surface of distal phalanx of horse (D), tibial condyle of cat (E), femoral head of monkey (F), femoral head of dog (G), trochlear notch of hyena (H), articular surface of tarsal bone of cattle (I), lumbar vertebra of human (J), and phalanx of Asian elephant (K).
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References

    1. Altman RD, Abramson S, Bruyere O, et al. (2006) Commentary: osteoarthritis of the knee and glucosamine. Osteoarthritis Cartilage 14, 963–966. - PubMed
    1. Arzi B, Cissell DD, Verstraete FJM, et al. (2013) Computed tomographic findings in dogs and cats with temporomandibular joint disorders: 58 cases (2006–2011). J Am Vet Med Assoc 242, 69–75. - PMC - PubMed
    1. Baldwin CL (1985) Management of Dugong: an Endangered Marine Species of Traditional Significance. Townsville, Qld: Great Barrier Reef Marine Park Authority.
    1. Bartels EM, Juhl CB, Christensen R, et al. (2016) Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev CD005523. - PMC - PubMed
    1. Björnsdóttir S, Axelsson M, Eksell P, et al. (2000) Radiographic and clinical survey of degenerative joint disease in the distal tarsal joints in Icelandic horses. Equine Vet J 32, 268–272. - PubMed

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