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. 2017 Nov;58(2):368-379.
doi: 10.1007/s12020-017-1273-x. Epub 2017 Mar 16.

Increased incidence trend of low-grade and high-grade neuroendocrine neoplasms

Emanuele Leoncini  1 , Paolo Boffetta  2 , Michail Shafir  3 , Katina Aleksovska  1 , Stefania Boccia  1 , Guido Rindi  4   5
Affiliations

Increased incidence trend of low-grade and high-grade neuroendocrine neoplasms

Emanuele Leoncini et al. Endocrine. 2017 Nov.

Abstract

Purpose: The incidence of neuroendocrine neoplasms is increasing. This work aimed at: (i) establishing worldwide incidence trend of low-grade neuroendocrine neoplasms; (ii) defining the incidence and temporal trend of high-grade neuroendocrine neoplasms in USA utilizing the Surveillance Epidemiology and End Results database; (iii) comparing trends for low-grade vs. high-grade neuroendocrine neoplasms.

Methods: We conducted a literature search on MEDLINE and Scopus databases and incidence trends were plotted for 1973-2012. The Surveillance Epidemiology and End Results database was used to identify incidence rates in USA for 1973-2012. Incidence rates were stratified according to histological grade, gender and ethnicity. Trends were summarized as annual percent change and corresponding 95% confidence interval.

Results: 11 studies were identified involving 72,048 cases; neuroendocrine neoplasm incidence rates increased over time in all countries for all sites, except for appendix. In Surveillance Epidemiology and End Results low-grade neuroendocrine neoplasm incidence rate increased from 1.09 in 1973 to 3.51 per 100,000 in 2012. During this interval, high-grade neuroendocrine neoplasm incidence rate increased from 2.54 to 10.52 per 100,000. African Americans had the highest rates of digestive neuroendocrine neoplasms with male prevalence in high-grade.

Conclusions: Our data indicate an increase in the incidence of neuroendocrine neoplasms as a worldwide phenomenon, affecting most anatomical sites and involving both low-grade and high-grade neoplasms.

Keywords: Cancer; High-grade; Incidence; Low-grade; Neuroendocrine.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of study selection
Fig. 2
Fig. 2
Countries with information available on trends in incidence of NENs
Fig. 3
Fig. 3
a International incidence of NENs overall per 100,000 persons; b Incidence of high-grade lung NEN, and low-grade and high-grade NENs per 100,000 persons in the United States, 1973–2012; c Incidence of low-grade NENs per 100,000 persons by primary site, in the United States, 1973–2012; d Incidence of high-grade NENs per 100,000 persons by primary site, in the United States, 1973–2012
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