Lipid peroxidation in cell death
- PMID: 28212725
- PMCID: PMC5319403
- DOI: 10.1016/j.bbrc.2016.10.086
Lipid peroxidation in cell death
Abstract
Disruption of redox homeostasis is a key phenotype of many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative stress, increasingly, attention is focused on the role of lipid hydroperoxides as critical mediators of death and disease. As the main component of cellular membranes, lipids have an indispensible role in maintaining the structural integrity of cells. Excessive oxidation of lipids alters the physical properties of cellular membranes and can cause covalent modification of proteins and nucleic acids. This review discusses the synthesis, toxicity, degradation, and detection of lipid peroxides in biological systems. Additionally, the role of lipid peroxidation is highlighted in cell death and disease, and strategies to control the accumulation of lipid peroxides are discussed.
Keywords: Antioxidant; Ferroptosis; Lipid oxidation; Neurodegeneration; Oxidation; Peroxidation.
Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.
Figures
Similar articles
-
Modeling the effects of lipid peroxidation during ferroptosis on membrane properties.Sci Rep. 2018 Mar 26;8(1):5155. doi: 10.1038/s41598-018-23408-0. Sci Rep. 2018. PMID: 29581451 Free PMC article.
-
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4966-75. doi: 10.1073/pnas.1603244113. Epub 2016 Aug 9. Proc Natl Acad Sci U S A. 2016. PMID: 27506793 Free PMC article.
-
Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives.Arch Biochem Biophys. 1995 Dec 1;324(1):15-25. doi: 10.1006/abbi.1995.9935. Arch Biochem Biophys. 1995. PMID: 7503550
-
[The present-day look at lipid peroxidation].Postepy Biochem. 2006;52(2):173-9. Postepy Biochem. 2006. PMID: 17078507 Review. Polish.
-
Lipid peroxidation: mechanisms, inhibition, and biological effects.Biochem Biophys Res Commun. 2005 Dec 9;338(1):668-76. doi: 10.1016/j.bbrc.2005.08.072. Epub 2005 Aug 19. Biochem Biophys Res Commun. 2005. PMID: 16126168 Review.
Cited by
-
Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity.Plants (Basel). 2024 May 18;13(10):1409. doi: 10.3390/plants13101409. Plants (Basel). 2024. PMID: 38794478 Free PMC article.
-
Effect of Alkyl Peroxyl Radical Oxidation on the Oxidative Stability of Walnut Protein Emulsions and Their Adsorbed Proteins.Foods. 2024 May 13;13(10):1513. doi: 10.3390/foods13101513. Foods. 2024. PMID: 38790813 Free PMC article.
-
Oxidative Stress, Lipid Peroxidation and Ferroptosis Are Major Pathophysiological Signatures in the Placental Tissue of Women with Late-Onset Preeclampsia.Antioxidants (Basel). 2024 May 11;13(5):591. doi: 10.3390/antiox13050591. Antioxidants (Basel). 2024. PMID: 38790696 Free PMC article.
-
Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production.Curr Issues Mol Biol. 2024 May 13;46(5):4646-4687. doi: 10.3390/cimb46050282. Curr Issues Mol Biol. 2024. PMID: 38785550 Free PMC article. Review.
-
Selenium May Be Involved in Esophageal Squamous Cancer Prevention by Affecting GPx3 and FABP1 Expression: A Case-Control Study Based on Bioinformatic Analysis.Nutrients. 2024 Apr 28;16(9):1322. doi: 10.3390/nu16091322. Nutrients. 2024. PMID: 38732573 Free PMC article.
References
-
- Turini ME, DuBois RN. Cyclooxygenase-2: a therapeutic target. Annu Rev Med. 2002;53:35–57. - PubMed
-
- Breuer W, Shvartsman M, Cabantchik ZI. Intracellular labile iron. Int J Biochem Cell Biol. 2008;40:350–354. - PubMed
-
- Marisa Repetto JS, Boveris Alberto. Lipid peroxidation: chemical mechanism, biological implications and analytical determination. In: Catala DA, editor. Lipid Peroxiation. InTech; 2012.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials