Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish
- PMID: 28184214
- PMCID: PMC5266698
- DOI: 10.3389/fendo.2017.00009
Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish
Abstract
Glucose homeostasis is an important element of energy balance and is conserved in organisms from fruit fly to mammals. Central to the control of circulating glucose levels in vertebrates are the endocrine cells of the pancreas, particularly the insulin-producing β-cells and the glucagon producing α-cells. A feature of α- and β-cells is their plasticity, an ability to adapt, in function and number as a response to physiological and pathophysiological conditions of increased hormone demand. The molecular mechanisms underlying these adaptive responses that maintain glucose homeostasis are incompletely defined. The zebrafish is an attractive model due to the low cost, high fecundity, and amenability to genetic and compound screens, and mechanisms governing the development of the pancreatic endocrine cells are conserved between zebrafish and mammals. Post development, both β- and α-cells of zebrafish display plasticity as in mammals. Here, we summarize the studies of pancreatic endocrine cell adaptation in zebrafish. We further explore the utility of the zebrafish as a model for diabetes, a relevant topic considering the increase in diabetes in the human population.
Keywords: glucose homeostasis; plasticity; regeneration; zebrafish; α-cell; β-cell.
Similar articles
-
Zebrafish pancreatic β cell clusters undergo stepwise regeneration using Neurod1-expressing cells from different cell lineages.Cell Tissue Res. 2023 Oct;394(1):131-144. doi: 10.1007/s00441-023-03805-2. Epub 2023 Jul 21. Cell Tissue Res. 2023. PMID: 37474621
-
Zebrafish as a model for studying functional pancreatic β cells development and regeneration.Dev Growth Differ. 2018 Aug;60(6):393-399. doi: 10.1111/dgd.12565. Dev Growth Differ. 2018. PMID: 30133710 Review.
-
Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies.Curr Top Dev Biol. 2017;124:235-276. doi: 10.1016/bs.ctdb.2016.10.005. Epub 2016 Dec 21. Curr Top Dev Biol. 2017. PMID: 28335861 Review.
-
Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.BMC Biol. 2017 Mar 21;15(1):21. doi: 10.1186/s12915-017-0362-x. BMC Biol. 2017. PMID: 28327131 Free PMC article.
-
Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.Development. 2015 Apr 15;142(8):1407-17. doi: 10.1242/dev.117911. Development. 2015. PMID: 25852199 Free PMC article.
Cited by
-
Zebrafish: A Model to Study and Understand the Diabetic Nephropathy and Other Microvascular Complications of Type 2 Diabetes Mellitus.Vet Sci. 2022 Jun 22;9(7):312. doi: 10.3390/vetsci9070312. Vet Sci. 2022. PMID: 35878329 Free PMC article. Review.
-
Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish.PLoS One. 2022 May 11;17(5):e0267933. doi: 10.1371/journal.pone.0267933. eCollection 2022. PLoS One. 2022. PMID: 35544474 Free PMC article.
-
In Vivo Toxicity Evaluation of Sugar Adulterated Heterotrigona itama Honey Using Zebrafish Model.Molecules. 2021 Oct 15;26(20):6222. doi: 10.3390/molecules26206222. Molecules. 2021. PMID: 34684803 Free PMC article.
-
Hypoglycemic Activity of Aqueous Extract of Latex from Hancornia speciosa Gomes: A Study in Zebrafish and In Silico.Pharmaceuticals (Basel). 2021 Aug 26;14(9):856. doi: 10.3390/ph14090856. Pharmaceuticals (Basel). 2021. PMID: 34577555 Free PMC article.
-
Zebrafish as a Model for Obesity and Diabetes.Front Cell Dev Biol. 2018 Aug 20;6:91. doi: 10.3389/fcell.2018.00091. eCollection 2018. Front Cell Dev Biol. 2018. PMID: 30177968 Free PMC article. Review.
References
-
- Herrgen L, Schröter C, Bajard L, Oates AC. Multiple embryo time-lapse imaging of zebrafish development. In: Lieschke GJ, Oates AC, Kawakami K, editors. Zebrafish: Methods and Protocols. Totowa, NJ: Humana Press; (2009). p. 243–54. - PubMed
-
- Hall C, Flores MV, Crosier K, Crosier P. Live cell imaging of zebrafish leukocytes. In: Lieschke GJ, Oates AC, Kawakami K, editors. Zebrafish: Methods and Protocols. Totowa, NJ: Humana Press; (2009). p. 255–71. - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources